Author

A. Locke

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Evolutionary Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:cell type annotation· 2 Organism:mouse· 2 Assay:proteomics· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1 Organism:Drosophila· 1

Frequent Co-Authors

A. Folch· 1 shared A. Munoz-Barrutia· 1 shared A. Sneider· 1 shared B. Starich· 1 shared C. Ahls· 1 shared C. Marar· 1 shared C. Stiles· 1 shared D. M. Lewis· 1 shared

Activity by Year

2021-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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1 shared paperCancer Biology

A. Folch

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Functional evaluation of microdissected tumor 'cuboids': a microscale ex vivo cancer model that retains a complex tumor microenvironment

L. F. Horowitz, R. A. Rodriguez-Mias, M. Chang, S. Zhu, Y. Tang, A. Locke, N. R. Gottshall, I. Stepanov, C. Stiles, M. Yeung, T. N. Nguyen, E. J. Lockhart, C. Ahls, E. Wayne, W. Wei, , A. Folch

The paper develops a microscale ex vivo cancer model using tumor cuboids that retain a complex tumor microenvironment, enabling drug and immunotherapy testing.

bioRxiv · Mar 22, 2024 · PreprintCancer Biology

Small extracellular vesicles promote stiffness-mediated metastasis

A. Sneider, Y. Liu, B. Starich, W. Du, C. Marar, N. Faqih, G. E. Ciotti, J. H. Kim, S. Krishnan, S. Ibrahim, M. Igboko, A. Locke, D. M. Lewis, H. Hong, M. Karl, , D. Wirtz

The paper shows that breast cancer cell-derived small extracellular vesicles (EVs) become more adhesive and metastatic when produced in stiff matrices, promoting cancer spread through enhanced chemotaxis and fibroblast reprogramming.

bioRxiv · Jul 1, 2023Cancer Biology

Heightened condition dependent expression of structural colouration in the faces, but not wings, of male and female flies

T. E. White, A. Locke, T. Latty

The paper examines structural coloration in flies, finding that facial colors correlate with individual condition, while wing colors do not, suggesting facial colors as honest signals of quality.

bioRxiv · Jun 9, 2021Evolutionary Biology