S. Ibrahim

Impact of variants and vaccination on nasal immunity across three waves of SARS-CoV-2

This study examines how SARS-CoV-2 variants and vaccination affect nasal immunity across three waves, identifying changes in cellular states and immune responses.

Small extracellular vesicles promote stiffness-mediated metastasis

The paper shows that breast cancer cell-derived small extracellular vesicles (EVs) become more adhesive and metastatic when produced in stiff matrices, promoting cancer spread through enhanced chemotaxis and fibroblast reprogramming.

Identification and characterization of the T cell receptor (TCR) repertoire of the Cynomolgus macaque (Macaca Fascicularis)

The paper characterizes the T cell receptor repertoire in Cynomolgus macaques using single-cell RNA sequencing and identifies similarities with human and Rhesus macaque TCR repertoires.

Curcumin and NCLX Inhibitors Share Anti-Tumoral Mechanisms in Microsatellite-Instability-Driven Colorectal Cancer

This study identifies NCLX as a therapeutic target in MSI-driven CRC, showing that curcumin and NCLX inhibitors induce anti-tumoral effects through mitochondrial calcium overload and apoptosis.

12-Lipoxygenase Governs the Innate Immune Pathogenesis of Islet Inflammation and Autoimmune Diabetes

This study shows that 12-LOX promotes islet inflammation and autoimmune diabetes by enhancing macrophage infiltration and migration via CXCR3.

Multimodal profiling of lung granulomas reveals cellular correlates of tuberculosis control

The paper identifies cellular and temporal factors associated with bacterial control in tuberculosis granulomas using multimodal data.

The role of AP-1 in self-sufficient proliferation and migration of cancer cells and its potential impact on an autocrine/paracrine loop.

This study investigates the role of AP-1 family members in cancer cell proliferation and migration under serum starvation, identifying an autocrine/paracrine loop involving Fra-1.