C. Adams

The Legionella collagen-like protein employs a unique binding mechanism for the recognition of host glycosaminoglycans

This study determines the crystal structure of Legionella collagen-like protein and reveals its unique binding mechanism for sulphated glycosaminoglycans.

Native and invasive populations of the ectomycorrhizal death cap Amanita phalloides are highly sexual but dispersal limited

The paper withdraws its previous analysis due to limitations in population genomic methods and plans to resubmit revised work.

Structure and Neutralization Mechanism of a Human Antibody Targeting a Complex Epitope on Zika Virus

This study defines the epitope and neutralization mechanism of a human antibody targeting Zika virus by showing that cross-linking of viral envelope proteins is critical for neutralization.

Discovery of a novel human antibody VH domain with potent activity against mesothelin expressing cancer cells in both CAR T-cell and antibody drug conjugate formats

The paper identifies a novel human antibody VH domain with high affinity for mesothelin and demonstrates its efficacy in both CAR-T cell and antibody drug conjugate formats against mesothelin-expressing cancer cells.

Potent Neutralization of Omicron and other SARS-CoV-2 Variants of Concern by Biparatopic Human VH Domains

This study identifies a biparatopic VH domain that neutralizes SARS-CoV-2 VOCs, including Omicron, with high potency in vitro and in a mouse model.

The benefits of merging passive and active tracking approaches: new insights into riverine migration by salmonid smolts

This study combines tracking methods to estimate mortality rates and causes during salmonid smolt migration, finding avian predation as the main cause.

Structure of the phosphoinositide 3-kinase p110γ-p101 complex reveals molecular mechanism of GPCR activation

The paper reports the cryo-EM structure of the p110γ-p101 complex, revealing how GPCR activation is mediated through interactions with Gβγ and identifying potential therapeutic targets.

Neutralization of European, South African, and United States SARS-CoV-2 mutants by a human antibody and antibody domains

The paper evaluates an antibody domain's ability to neutralize SARS-CoV-2 variants with mutations in the RBD, showing it neutralizes the triple mutation variant but not others.

Functional analysis of the fatty acid and alcohol metabolism of Pseudomonas putida using RB-TnSeq

This study uses RB-TnSeq to functionally analyze fatty acid and alcohol metabolism in Pseudomonas putida, identifying gene roles and catabolic pathways for isoprenol and isopentanol.

Mass Spectrometric Characterization of Narcolepsy-Associated Pandemic 2009 Influenza Vaccines.

This study uses mass spectrometry to compare mutations in Pandemrix and Arepanrix vaccines, finding differences in protein modifications that may explain varying narcolepsy risks.

Arctic charr phenotypic responses to abrupt temperature change: an insight into how cold water fish could respond to extreme climatic events.

This study shows Arctic charr can rapidly change their head shape in response to a 4°C temperature increase, reducing phenotypic variation and resembling a benthivorous ecotype.

In-situ non-lethal rapid test to accurately detect the presence of the nematode parasite, Anguillicoloides crassus, in European eel, Anguilla anguilla.

The paper develops a non-lethal, rapid environmental DNA method to detect Anguillicoloides crassus in European eels using in situ extraction and PCR, achieving high predictive values.

Skeletal muscle DNMT3A plays a necessary role in endurance exercise by regulating oxidative capacity of red muscles

This study shows that DNMT3A in skeletal muscle regulates oxidative capacity and endurance exercise by controlling ROS production through ALDH1L1.

Bombs and cocaine: detecting nefarious nitrogen sources using remote sensing and machine learning

This study uses remote sensing and machine learning to detect illicit nitrogen sources in plants by analyzing reflectance signatures and metabolomic changes.

A phenotypically plastic magic trait promoting reproductive isolation in sticklebacks?

This study shows that an environmentally induced plastic trait in sticklebacks influences mate choice and contributes to reproductive isolation.