Author

I. Castillo

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 2 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 3 Research Focus:drug response / drug discovery· 1 Assay:flow cytometry· 1 Organism:human· 1 Organism:mouse· 1 Assay:proteomics· 1 Assay:structural biology· 1

Frequent Co-Authors

M. T. Heise· 2 shared P. Lakshmanane· 2 shared A. C. P. Ana C. Puhl· 1 shared A. Grifoni· 1 shared A. K. Falconar· 1 shared A. M. de Silva· 1 shared A. Schaefer· 1 shared A. Sette· 1 shared

Activity by Year

2022-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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2 shared papersImmunology

M. T. Heise

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Chikungunya-virus-specific CD4+ T cells are associated with chronic chikungunya viral arthritic disease in humans

J. Chang, R. Agarwal, F. H. Cortes, C. Ha, J. Villalpando, I. Castillo, R. I. Galvez, A. Grifoni, A. Sette, C. M. Romero-Vivas, M. T. Heise, P. Lakshmanane, A. K. Falconar, D. Weiskopf

This study identifies CHIKV-specific CD4+ T cell responses in chronic CHIKVD patients, showing stronger responses and Th17 enrichment compared to resolved infection.

bioRxiv · Nov 20, 2023 · PreprintImmunology

Fc mediated pan-sarbecovirus protection after alphavirus vector vaccination

L. E. Adams, S. R. Leist, K. H. Dinnon, A. West, K. L. Gully, E. Anderson, J. F. Loome, E. Madden, J. Powers, A. Schaefer, S. Sarkar, I. Castillo, J. Maron, R. P. McNamara, H. L. Bertera, , R. S. Baric

This study shows that non-neutralizing antibodies targeting FcR4 and spike S2 provide cross-protection against sarbecoviruses after alphavirus vector vaccination.

bioRxiv · Nov 28, 2022Microbiology

Structure and Neutralization Mechanism of a Human Antibody Targeting a Complex Epitope on Zika Virus

C. Adams, D. L. Carbaugh, B. Sho, T.-S. Ng, I. Castillo, R. Bhowmik, B. Segovia-Chumbez, A. C. P. Ana C. Puhl, S. Graham, s. diehl, H. Lazear, A. M. de Silva, S.-m. Lok, L. Premkumar

This study defines the epitope and neutralization mechanism of a human antibody targeting Zika virus by showing that cross-linking of viral envelope proteins is critical for neutralization.

bioRxiv · Aug 22, 2022Microbiology