Author

J. S. Klassen

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Biophysics· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 2 Organism:human· 2 Assay:proteomics· 2 Research Focus:cell type annotation· 1 Approach:deep learning· 1 Research Focus:protein folding & dynamics· 1 Assay:structural biology· 1

Frequent Co-Authors

M. S. Macauley· 3 shared D. T. Bui· 2 shared E. N. Kitova· 2 shared E. Rodrigues· 2 shared F. Mozaneh· 2 shared J. Jung· 2 shared L. Nguyen· 2 shared A. Bhattacherjee· 1 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 28 mutual co-author links

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3 shared papersBiochemistry

M. S. Macauley

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Author profile →

4 papers

Recent·Most cited

GotGlycans: Role of N343 Glycosylation on the SARS-CoV-2 S RBD Structure and Co-Receptor Binding Across Variants of Concern

C. M. Ives, L. Nguyen, C. A. Fogarty, A. M. Harbison, Y. Durocher, J. S. Klassen, e. fadda

This study investigates how N343 glycosylation affects the structure and co-receptor binding of the SARS-CoV-2 S RBD across variants of concern using molecular dynamics simulations.

bioRxiv · Dec 5, 2023Biophysics

Carbohydrate sulfation as a mechanism for fine-tuning Siglec ligands

J. Jung, J. R. Enterina, D. T. Bui, F. Mozaneh, P.-H. Lin, H. Nitin, C.-W. Kuo, E. Rodrigues, A. Bhattacherjee, P. Raeisimakiani, G. C. Daskhan, C. D. St. Laurent, K.-H. Khoo, L. K. Mahal, W. F. Zandberg, , M. S. Macauley

This study shows that specific sulfate modifications on Siglec ligands, mediated by CHSTs, can enhance or reduce Siglec binding, with implications for cancer immune evasion.

ACS Chemical Biology · Oct 18, 2021Peer-reviewedImmunology

Sialic acid-Dependent Binding and Viral Entry of SARS-CoV-2

L. Nguyen, K. A. McCord, D. T. Bui, K. A. Bouwman, E. N. Kitova, D. Kumawat, G. C. Daskan, I. Tomris, L. Han, P. Chopra, T.-J. Yang, S. D. Williows, T. L. Lowary, L. J. West, S.-T. D. Hsu, , J. S. Klassen

This study shows SARS-CoV-2 RBD binds sialylated glycans, particularly gangliosides, and that reducing cell surface sialic acid decreases viral entry.

bioRxiv · Mar 8, 2021Biochemistry

A Versatile Soluble Siglec Scaffold for Sensitive and Quantitative Detection of Glycan Ligands

E. Rodrigues, J. Jung, H. Park, C. Loo, S. Soukhtehzari, E. N. Kitova, F. Mozaneh, G. Daskhan, V. Aghanya, S. Sarkar, L. Streith, C. St. Laurent, J.-P. Julien, L. C. West, K. C. Williams, , M. S. Macauley

This paper introduces a versatile Siglec-Fc scaffold for detecting glycan ligands, revealing new patterns on healthy and cancerous cells and clarifying ligand specificities, including for CD33.

bioRxiv · Jul 28, 2020Biochemistry