Author

A. M. Lau

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:bacteria (other)· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:host-pathogen & immune response· 1 Research Focus:protein folding & dynamics· 1 Assay:protein structure· 1 Assay:proteomics· 1 Approach:simulation· 1

Frequent Co-Authors

A. Politis· 2 shared P. J. Booth· 2 shared A. Konijnenberg· 1 shared A. V. Vargiu· 1 shared C. Fais· 1 shared C. Martens· 1 shared E. Grimsey· 1 shared E. Reading· 1 shared

Activity by Year

2020-2020 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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2 shared papersBiochemistry

A. Politis

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Author profile →

2 papers

Recent·Most cited

Perturbed structural dynamics underlie inhibition and altered specificity of the multidrug efflux pump AcrB

E. Reading, Z. Ahdash, C. Fais, V. Ricci, X. Wang-Kan, E. Grimsey, J. W. Stone, G. Malloci, A. M. Lau, H. Findlay, A. Konijnenberg, P. J. Booth, P. Ruggerone, A. V. Vargiu, L. J. V. Piddock, A. Politis

The paper investigates the structural dynamics of the AcrB efflux pump, showing how inhibitors and mutations affect its function and substrate specificity.

bioRxiv · Apr 27, 2020Biochemistry

Hydrogen-deuterium exchange mass spectrometry captures distinct dynamics upon substrate and inhibitor binding to a transporter

R. Jia, C. Martens, M. Shekhar, S. Pant, G. A. Pellowe, A. M. Lau, H. E. Findlay, N. J. Harris, E. Tajkhorshid, P. J. Booth, A. Politis

The paper uses HDX-MS, mutagenesis, and MD simulations to show that substrate binding and protonation drive conformational changes in a transporter, while inhibitors prevent this transition.

bioRxiv · Apr 3, 2020Biochemistry