Author

A. M. Malinen

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 3 Biochemistry· 1

Signature Assays, Organisms & Methods

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Organism:bacteria (other)· 3 Research Focus:cell signaling & trafficking· 2 Approach:experimental assay· 2 Approach:microscopy & imaging analysis· 2 Approach:biophysical modeling· 1 Research Focus:chromatin & epigenetic regulation· 1 Assay:fluorescence / live-cell microscopy· 1 Assay:proteomics· 1

Frequent Co-Authors

D. Dulin· 3 shared A. N. Kapanidis· 2 shared M. Depken· 2 shared A. Kapanidis· 1 shared A. Kulbachinskiy· 1 shared A. Mazumder· 1 shared D. Duchi· 1 shared D. L. Bauer· 1 shared

Activity by Year

2017-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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3 shared papersBiophysics

D. Dulin

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Quantitative parameters of bacterial RNA polymerase open-complex formation, stabilization and disruption on a consensus promoter

S. C. Bera, P. P. B. America, S. Maatsola, M. Seifert, E. Ostrofet, J. Cnossen, M. Spermann, F. S. Papini, M. Depken, A. M. Malinen, D. Dulin

The paper quantifies the kinetics of bacterial RNA polymerase open-complex formation, stabilization, and disruption on a consensus promoter using single-molecule magnetic tweezers.

bioRxiv · Oct 13, 2021Biophysics

The formation of the bacterial RNA polymerase-promoter open complex involves a branched pathway

A. M. Malinen, J. Bakermans, E. Aalto-Setälä, M. Blessing, D. L. Bauer, O. Parilova, G. A. Belogurov, D. Dulin, A. N. Kapanidis

This study uses single-molecule fluorescence microscopy to show that bacterial RNA polymerase-promoter open complex formation follows a branched pathway with varying stability.

bioRxiv · Mar 27, 2021 · PreprintBiochemistry

The RNA polymerase clamp interconverts dynamically among three states and is stabilized in a partly closed state by ppGpp

D. Duchi, A. Mazumder, A. M. Malinen, R. Ebright, A. Kapanidis

This study uses single-molecule FRET to show RNA polymerase clamp interconverts among three states, with ppGpp stabilizing the partly closed state during transcription.

bioRxiv · Mar 8, 2018Biophysics

Pausing controls branching between productive and non-productive pathways during initial transcription

D. Dulin, D. L. V. Bauer, A. M. Malinen, J. J. W. Bakermans, M. Kaller, Z. Morichaud, I. Petushkov, M. Depken, K. Brodolin, A. Kulbachinskiy, A. N. Kapanidis

The paper investigates how RNA polymerase pausing controls transcriptional pathways in bacteria, showing that paused RNA synthesis directs RNAP to productive or abortive pathways.

bioRxiv · Oct 6, 2017Biophysics