Author

S. C. Bera

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 4

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:virus· 2 Organism:bacteria (other)· 1 Research Focus:cell signaling & trafficking· 1 Assay:fluorescence / live-cell microscopy· 1 Research Focus:host-pathogen & immune response· 1 Approach:statistical model· 1

Frequent Co-Authors

D. Dulin· 3 shared F. S. Papini· 3 shared M. Depken· 3 shared M. Seifert· 3 shared B. Canard· 2 shared C. E. Cameron· 2 shared J. J. Arnold· 2 shared P. van Nies· 2 shared

Activity by Year

2020-2021 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 40 mutual co-author links

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3 shared papersBiophysics

D. Dulin

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Author profile →

4 papers

Recent·Most cited

Quantitative parameters of bacterial RNA polymerase open-complex formation, stabilization and disruption on a consensus promoter

S. C. Bera, P. P. B. America, S. Maatsola, M. Seifert, E. Ostrofet, J. Cnossen, M. Spermann, F. S. Papini, M. Depken, A. M. Malinen, D. Dulin

The paper quantifies the kinetics of bacterial RNA polymerase open-complex formation, stabilization, and disruption on a consensus promoter using single-molecule magnetic tweezers.

bioRxiv · Oct 13, 2021Biophysics

Two step aggregation kinetics of Amyloid-β proteins from fractal analysis

S. Mukhopadhyay, S. C. Bera, K. Ramola

This study uses fractal analysis of TIRF microscopy images to identify two-step aggregation kinetics of Amyloid-β proteins, showing a transition from linear growth to branching.

bioRxiv · Jul 30, 2021 · PreprintBiophysics

The nucleotide addition cycle of the SARS-CoV-2 polymerase

S. C. Bera, M. Seifert, R. Kirchdoerfer, P. van Nies, Y. Wubulikasimu, S. Quack, F. S. Papini, J. J. Arnold, B. Canard, C. E. Cameron, M. Depken, D. Dulin

This study describes the mechanochemical behavior of the SARS-CoV-2 polymerase using magnetic tweezers, revealing three catalytic conformations and a thermal ratchet mechanism for nucleotide incorporation.

bioRxiv · Mar 27, 2021Biophysics

Inhibition of SARS-CoV-2 polymerase by nucleotide analogs: a single moleculeperspective

M. Seifert, S. C. Bera, P. van Nies, R. N. Kirchdoerfer, A. Shannon, T.-T.-N. Le, X. Meng, H. Xia, J. M. Wood, L. D. Harris, F. S. Papini, J. J. Arnold, S. C. Almo, T. L. Grove, P.-Y. Shi, , D. Dulin

This study investigates how nucleotide analogs like Remdesivir affect SARS-CoV-2 polymerase activity using single-molecule techniques, revealing backtracking rather than termination and evasion of ddhCTP.

bioRxiv · Aug 6, 2020 · PreprintBiophysics