Author

F. S. Papini

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Biophysics· 5

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 5 Organism:virus· 3 Organism:bacteria (other)· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:host-pathogen & immune response· 1 Approach:mechanistic / dynamical model· 1

Frequent Co-Authors

D. Dulin· 5 shared M. Seifert· 5 shared M. Depken· 4 shared C. E. Cameron· 3 shared J. J. Arnold· 3 shared P. van Nies· 3 shared S. C. Bera· 3 shared B. Canard· 2 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 40 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

5 shared papersBiophysics

D. Dulin

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Temperature-dependent twist of double-stranded RNA probed by magnetic tweezers experiments and molecular dynamics simulations

H. Dohnalova, M. Seifert, E. Matouskova, F. S. Papini, J. Lipfert, D. Dulin, F. Lankas

This study investigates how temperature affects the twist of double-stranded RNA using magnetic tweezers and molecular dynamics simulations, finding RNA unwinds more than DNA with increasing temperature.

bioRxiv · May 31, 2023Biophysics

Quantitative parameters of bacterial RNA polymerase open-complex formation, stabilization and disruption on a consensus promoter

S. C. Bera, P. P. B. America, S. Maatsola, M. Seifert, E. Ostrofet, J. Cnossen, M. Spermann, F. S. Papini, M. Depken, A. M. Malinen, D. Dulin

The paper quantifies the kinetics of bacterial RNA polymerase open-complex formation, stabilization, and disruption on a consensus promoter using single-molecule magnetic tweezers.

bioRxiv · Oct 13, 2021Biophysics

The nucleotide addition cycle of the SARS-CoV-2 polymerase

S. C. Bera, M. Seifert, R. Kirchdoerfer, P. van Nies, Y. Wubulikasimu, S. Quack, F. S. Papini, J. J. Arnold, B. Canard, C. E. Cameron, M. Depken, D. Dulin

This study describes the mechanochemical behavior of the SARS-CoV-2 polymerase using magnetic tweezers, revealing three catalytic conformations and a thermal ratchet mechanism for nucleotide incorporation.

bioRxiv · Mar 27, 2021Biophysics

Inhibition of SARS-CoV-2 polymerase by nucleotide analogs: a single moleculeperspective

M. Seifert, S. C. Bera, P. van Nies, R. N. Kirchdoerfer, A. Shannon, T.-T.-N. Le, X. Meng, H. Xia, J. M. Wood, L. D. Harris, F. S. Papini, J. J. Arnold, S. C. Almo, T. L. Grove, P.-Y. Shi, , D. Dulin

This study investigates how nucleotide analogs like Remdesivir affect SARS-CoV-2 polymerase activity using single-molecule techniques, revealing backtracking rather than termination and evasion of ddhCTP.

bioRxiv · Aug 6, 2020 · PreprintBiophysics

Temperature controlled high-throughput magnetic tweezers show striking difference in activation energies of replicating viral RNA-dependent RNA polymerases.

M. Seifert, P. van Nies, F. S. Papini, J. J. Arnold, M. M. Poranen, C. E. Cameron, M. Depken, D. Dulin

This study uses temperature-controlled magnetic tweezers to compare replication kinetics of RdRps from three RNA viruses, finding temperature-dependent activation differences.

bioRxiv · Jan 15, 2020Biophysics