Structural basis of the regulation of normal and oncogenic methylation of nucleosomal histone H3 Lys36 by NSD2
K. Sato, A. Kumar, K. Hamada, C. Okada, A. Oguni, A. Machiyama, S. Sakuraba, T. Nishizawa, O. Nureki, H. Kono, K. Ogata, T. Sengoku
This study determines the cryo-EM structure of NSD2 bound to a nucleosome and identifies oncogenic mutations that increase its catalytic activity by altering the autoinhibitory loop conformation.
Nature Communications · Nov 15, 2021Peer-reviewedBiochemistry