Author

H. Kono

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 3 Biochemistry· 1 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:chromatin & epigenetic regulation· 2 Approach:experimental assay· 2 Organism:human· 2 Approach:statistical model· 2 Research Focus:benchmarking· 1 Assay:ChIP-seq· 1 Approach:deep learning· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

S. Sakuraba· 2 shared A. Kumar· 1 shared A. Machiyama· 1 shared A. Martel· 1 shared A. Oguni· 1 shared A. Osakabe· 1 shared B. Ma· 1 shared C. Okada· 1 shared

Activity by Year

2019-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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2 shared papersBiophysics

S. Sakuraba

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Benchmark of force fields to characterize the intrinsically disordered R2-FUS-LC region

M. Chan-Yao-Chong, J. Chan, H. Kono

The paper benchmarks thirteen force fields to assess their ability to simulate the behavior of the intrinsically disordered R2-FUS-LC region and its aggregation into cross-β amyloid fibrils.

bioRxiv · Dec 20, 2022Biophysics

Fly-casting with ligand-sliding and orientational selection to support the complex formation of a GPCR and a middle-sized flexible molecule

J. Higo, K. Kasahara, G.-J. Bekker, B. Ma, S. Sakuraba, S. Iida, N. Kamiya, I. Fukuda, H. Kono, Y. Fukunishi, H. Nakamura

This paper uses a computational method to simulate the binding mechanism of bosentan to hETB, identifying key steps like fly-casting and ligand-sliding.

bioRxiv · Feb 28, 2022 · PreprintBiophysics

Structural basis of the regulation of normal and oncogenic methylation of nucleosomal histone H3 Lys36 by NSD2

K. Sato, A. Kumar, K. Hamada, C. Okada, A. Oguni, A. Machiyama, S. Sakuraba, T. Nishizawa, O. Nureki, H. Kono, K. Ogata, T. Sengoku

This study determines the cryo-EM structure of NSD2 bound to a nucleosome and identifies oncogenic mutations that increase its catalytic activity by altering the autoinhibitory loop conformation.

Nature Communications · Nov 15, 2021Peer-reviewedBiochemistry

Inhibitory effect of an anti-prokineticin-1 antibody on liver metastasis in mice injected with human colorectal cancer cell lines

H. KONO, T. Goi, H. Kurebayashi, K. Sawai, M. Morikawa, K. Koneri

This study shows that an anti-PROK1 antibody reduces liver metastases and extends survival in mice with human colorectal cancer.

bioRxiv · Aug 5, 2021 · PreprintCancer Biology

Structural Studies of Overlapping Dinucleosomes in Solution

M. Atsushi, M. Sugiyama, H. Kono, H. Kurumizaka, A. Martel, L. Porcar, Z. Li, A. Osakabe, D. Kato, R. Inoue

The paper investigates the solution structure of overlapping dinucleosomes using SAXS, SANS, modeling, and simulations, showing histone tails stabilize their conformations.

bioRxiv · Aug 30, 2019Biophysics