Author

T. Sengoku

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:cell type annotation· 2 Research Focus:chromatin & epigenetic regulation· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cell-cell communication· 1 Assay:ChIP-seq· 1 Assay:cryo-EM· 1

Frequent Co-Authors

C. Okada· 2 shared K. Ogata· 2 shared K. Sato· 2 shared O. Nureki· 2 shared T. Nishizawa· 2 shared A. Ishiwata· 1 shared A. Kumar· 1 shared A. Machiyama· 1 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 28 mutual co-author links

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2 shared papersBiochemistry

C. Okada

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Genetic and functional diversity of beta-N-acetylgalactosamine residue-targeting glycosidases expanded by deep-sea metagenome

T. Sumida, S. Hiraoka, K. Usui, A. Ishiwata, T. Sengoku, K. A. Stubbs, K. Tanaka, S. Deguchi, S. Fushinobu, T. Nunoura

This study identifies and characterizes novel beta-N-acetylgalactosaminidases from deep-sea metagenomes, revealing structural diversity and substrate specificity expansion.

bioRxiv · Jul 28, 2023Biochemistry

Structure of the human Bre1 complex bound to the nucleosome

S. Onishi, K. Uchiyama, K. Sato, C. Okada, S. Kobayashi, T. Nishizawa, O. Nureki, K. Ogata, T. Sengoku

The paper determines the cryo-EM structure of the human Bre1 complex bound to the nucleosome, revealing how it catalyzes H2B monoubiquitination and its potential role in cancer.

bioRxiv · Mar 31, 2023Biochemistry

Structural basis of the regulation of normal and oncogenic methylation of nucleosomal histone H3 Lys36 by NSD2

K. Sato, A. Kumar, K. Hamada, C. Okada, A. Oguni, A. Machiyama, S. Sakuraba, T. Nishizawa, O. Nureki, H. Kono, K. Ogata, T. Sengoku

This study determines the cryo-EM structure of NSD2 bound to a nucleosome and identifies oncogenic mutations that increase its catalytic activity by altering the autoinhibitory loop conformation.

Nature Communications · Nov 15, 2021Peer-reviewedBiochemistry

Modulation of the combinatorial code of odorant receptor response patterns in odorant mixtures

C. A. de March, W. B. Titlow, T. Sengoku, P. Breheny, H. Matsunami, T. S. McClintock

The paper identifies OR response patterns to odorants and mixtures in mice, showing common interactions that explain olfactory phenomena.

bioRxiv · Jan 15, 2020Cell Biology