T. Nishizawa

Structure of the human Bre1 complex bound to the nucleosome

The paper determines the cryo-EM structure of the human Bre1 complex bound to the nucleosome, revealing how it catalyzes H2B monoubiquitination and its potential role in cancer.

Structural basis of the regulation of normal and oncogenic methylation of nucleosomal histone H3 Lys36 by NSD2

This study determines the cryo-EM structure of NSD2 bound to a nucleosome and identifies oncogenic mutations that increase its catalytic activity by altering the autoinhibitory loop conformation.

Tandem mass spectrum similarity-based network analysis using 13C-labeled and non-labeled metabolome data to identify the biosynthesis pathway of the blood pressure-lowering asparagus metabolite asparaptine A

The paper identifies the biosynthesis pathway of asparaptine A using metabolome network analysis and shows its blood pressure-lowering effects in mice.

Cryo-EM structures of SERCA2b reveal the mechanism of regulation by the luminal extension tail

Cryo-EM structures of SERCA2b reveal how the luminal extension tail regulates its activity by controlling conformational transitions between states.

Cryo-EM structures capturing the entire transport cycle of the P4-ATPase flippase

The paper reports cryo-EM structures of six intermediates in the ATP8A1-CDC50a flippase cycle, revealing the mechanism of phospholipid translocation.

Cryo-EM structure of the human L-type amino acid transporter 1 in complex with glycoprotein CD98hc

This paper reports the cryo-EM structure of the human LAT1-CD98hc heterodimer, revealing its architecture and interactions, and maps disease mutations to explain congenital disorders.

Structure of the triose-phosphate/phosphate translocator reveals the basis of substrate specificity

This study determines the crystal structures of TPT bound to substrates, revealing the molecular basis of its strict 1:1 exchange mechanism.