Author

C. Okada

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2

Signature Assays, Organisms & Methods

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Research Focus:chromatin & epigenetic regulation· 2 Approach:experimental assay· 2 Organism:human· 2 Assay:ChIP-seq· 1 Assay:cryo-EM· 1

Frequent Co-Authors

K. Ogata· 2 shared K. Sato· 2 shared O. Nureki· 2 shared T. Nishizawa· 2 shared T. Sengoku· 2 shared A. Kumar· 1 shared A. Machiyama· 1 shared A. Oguni· 1 shared

Activity by Year

2020-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersBiochemistry

K. Ogata

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2 papers

Recent·Most cited

Structure of the human Bre1 complex bound to the nucleosome

S. Onishi, K. Uchiyama, K. Sato, C. Okada, S. Kobayashi, T. Nishizawa, O. Nureki, K. Ogata, T. Sengoku

The paper determines the cryo-EM structure of the human Bre1 complex bound to the nucleosome, revealing how it catalyzes H2B monoubiquitination and its potential role in cancer.

bioRxiv · Mar 31, 2023Biochemistry

Structural basis of the regulation of normal and oncogenic methylation of nucleosomal histone H3 Lys36 by NSD2

K. Sato, A. Kumar, K. Hamada, C. Okada, A. Oguni, A. Machiyama, S. Sakuraba, T. Nishizawa, O. Nureki, H. Kono, K. Ogata, T. Sengoku

This study determines the cryo-EM structure of NSD2 bound to a nucleosome and identifies oncogenic mutations that increase its catalytic activity by altering the autoinhibitory loop conformation.

bioRxiv · Dec 5, 2020Biochemistry