Tumor growth of neurofibromin-deficient cells is driven by decreased respiration and hampered by NAD+ and SIRT3
I. Masgras, G. Cannino, F. Ciscato, C. Sanchez-Martin, M. Pizzi, A. Menga, A. Castegna, A. Rasola
This study shows that neurofibromin loss reduces mitochondrial respiration and NAD+ levels, promoting tumor growth, and that restoring NAD+ or SIRT3 can counteract this effect.
bioRxiv · May 29, 2021Cancer Biology