Author

I. Masgras

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Biochemistry· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:cancer & tumor microenvironment· 3 Research Focus:cell signaling & trafficking· 3 Research Focus:cell type annotation· 2 Organism:human· 2 Research Focus:metabolism & bioenergetics· 2 Assay:proteomics· 2 Research Focus:development & morphogenesis· 1

Frequent Co-Authors

A. Rasola· 4 shared F. Ciscato· 3 shared P. Bernardi· 3 shared C. Sanchez-Martin· 2 shared G. Cannino· 2 shared M. Pizzi· 2 shared A. Castegna· 1 shared A. Filippi· 1 shared

Activity by Year

2019-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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4 shared papersCancer Biology

A. Rasola

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

TRAP1 and cyclophilin D compete at OSCP subunit to regulate enzymatic activity and permeability transition pore opening by F-ATP synthase

G. Cannino, A. Urbani, M. Gaspari, M. Varano, A. Negro, A. Filippi, F. Ciscato, I. Masgras, C. Gerle, E. Tibaldi, A. M. Brunati, G. Lippe, P. Bernardi, A. Rasola

bioRxiv · Dec 6, 2021Cell Biology

Tumor growth of neurofibromin-deficient cells is driven by decreased respiration and hampered by NAD+ and SIRT3

I. Masgras, G. Cannino, F. Ciscato, C. Sanchez-Martin, M. Pizzi, A. Menga, A. Castegna, A. Rasola

This study shows that neurofibromin loss reduces mitochondrial respiration and NAD+ levels, promoting tumor growth, and that restoring NAD+ or SIRT3 can counteract this effect.

bioRxiv · May 29, 2021Cancer Biology

HIF1a-dependent induction of the mitochondrial chaperone TRAP1 regulates bioenergetic adaptations to hypoxia

A. Rasola, C. Laquatra, C. Sanchez-Martin, G. Minervini, E. Moroni, M. Schiavone, S. C. E. Tosatto, F. Argenton, G. Colombo, P. Bernardi, I. Masgras

This study identifies TRAP1 as a HIF1a-dependent regulator of mitochondrial bioenergetics in hypoxic conditions, showing its role in maintaining respiration in developing embryos and cancer models.

bioRxiv · Sep 23, 2020Biochemistry

Hexokinase 2 displacement from mitochondria-associated membranes prompts Ca2+-dependent death of cancer cells

A. Rasola, F. Ciscato, R. Filadi, I. Masgras, M. Pizzi, O. Marin, N. Damiano, P. Pizzo, A. Gori, F. Frezzato, L. Trentin, P. Bernardi

The paper shows that displacing HK2 from MAMs triggers Ca2+-dependent death of cancer cells, offering a potential anti-neoplastic strategy.

bioRxiv · Aug 15, 2019Cancer Biology