G. Cannino

TRAP1 and cyclophilin D compete at OSCP subunit to regulate enzymatic activity and permeability transition pore opening by F-ATP synthase

Tumor growth of neurofibromin-deficient cells is driven by decreased respiration and hampered by NAD+ and SIRT3

This study shows that neurofibromin loss reduces mitochondrial respiration and NAD+ levels, promoting tumor growth, and that restoring NAD+ or SIRT3 can counteract this effect.