Targeted nanocarriers coopting pulmonary leukocytes for drug delivery to the injured brain
P. M. Glassman, J. Nong, J. W. Myerson, V. Zuluaga-Ramirez, A. Rodriguez-Garcia, A. Mukalel, S. Omo-Lamai, L. R. Walsh, R. Y. Kiseleva, C. H. Villa, C. F. Greineder, S. E. Kasner, D. Weissman, M. J. Mitchell, S. Muro, , O. A. Marcos-Contreras
This paper demonstrates a strategy for targeted drug delivery to the injured brain by loading drugs onto pulmonary leukocytes using ICAM-targeting nanocarriers, showing increased brain uptake and therapeutic effect in a mouse model.
bioRxiv · Feb 4, 2022 · PreprintPharmacology & Toxicology