Author

J. W. Myerson

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 3 Pharmacology & Toxicology· 2 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Research Focus:drug response / drug discovery· 5 Organism:mouse· 3 Research Focus:cell type annotation· 2 Research Focus:host-pathogen & immune response· 2 Organism:human· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell-cell communication· 1

Frequent Co-Authors

J. S. Brenner· 6 shared J. Nong· 5 shared O. A. Marcos-Contreras· 5 shared M. E. Zamora· 4 shared S. Omo-Lamai· 4 shared J. Wu· 3 shared P. M. Glassman· 3 shared R. Y. Kiseleva· 3 shared

Activity by Year

2020-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 41 mutual co-author links

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6 shared papersBioengineering

J. S. Brenner

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Author profile →

6 papers

Recent·Most cited

A combination of physicochemical tropism and affinity moiety targeting of lipid nanoparticles enhances organ targeting

M. E. Zamora, S. Omo-Lamai, M. N. Patel, J. Wu, E. Arguiri, V. Muzykantov, J. W. Myerson, O. A. Marcos-Contreras, J. S. Brenner

This paper combines affinity moiety targeting and physicochemical tropism in lipid nanoparticles to enhance organ targeting, showing improved specificity and uptake in lungs and brain.

bioRxiv · Nov 21, 2023Bioengineering

Physicochemical Targeting of Lipid Nanoparticles to the Lungs Induces Clotting: Mechanisms and Solutions

S. Omo-Lamai, M. E. Zamora, M. N. Patel, J. Wu, J. Nong, Z. Wang, A. Peshkova, L. S. Chase, E.-O. Essien, V. Muzykantov, O. A. Marcos-Contreras, J. W. Myerson, J. S. Brenner

This study identifies thrombosis as a risk of lung-targeted cationic lipid nanoparticles and proposes solutions to mitigate clotting without compromising targeting.

bioRxiv · Jul 21, 2023Bioengineering

Targeting lipid nanoparticles to the blood brain barrier to ameliorate acute ischemic stroke

J. Nong, P. M. Glassman, S. Reyes-Esteves, H. C. Descamps, V. V. Shuvaev, R. Y. Kiseleva, T. E. Papp, M.-G. Alameh, Y. K. Tam, B. L. Mui, S. Omo-Lamai, M. E. Zamora, T. Shuvaeva, E. Arguiri, C. A. Thaiss, , O. A. Marcos-Contreras

This paper develops VCAM-targeted lipid nanoparticles to enhance drug delivery to the blood-brain barrier in acute ischemic stroke, reducing infarct volume and mortality.

bioRxiv · Jun 12, 2023Pharmacology & Toxicology

Nanoparticle-induced augmentation of neutrophils' phagocytosis of bacteria

K. Rubey, A. R. Mukhitov, J. Nong, J. Wu, V. P. Krymskaya, J. W. Myerson, G. S. Worthen, J. S. Brenner

This study shows that neutrophil-tropic nanoparticles enhance phagocytosis of non-opsonized bacteria by ~50%, suggesting their potential as drug carriers for bacterial infections.

bioRxiv · May 14, 2022 · PreprintImmunology

Targeted nanocarriers coopting pulmonary leukocytes for drug delivery to the injured brain

P. M. Glassman, J. Nong, J. W. Myerson, V. Zuluaga-Ramirez, A. Rodriguez-Garcia, A. Mukalel, S. Omo-Lamai, L. R. Walsh, R. Y. Kiseleva, C. H. Villa, C. F. Greineder, S. E. Kasner, D. Weissman, M. J. Mitchell, S. Muro, , O. A. Marcos-Contreras

This paper demonstrates a strategy for targeted drug delivery to the injured brain by loading drugs onto pulmonary leukocytes using ICAM-targeting nanocarriers, showing increased brain uptake and therapeutic effect in a mouse model.

bioRxiv · Feb 4, 2022 · PreprintPharmacology & Toxicology

Supramolecular Organization Predicts Protein Nanoparticle Delivery to Neutrophils for Acute Lung Inflammation Diagnosis and Treatment

J. W. Myerson, P. N. Patel, N. Habibi, L. R. Walsh, Y.-W. Lee, D. C. Luther, L. T. Ferguson, M. H. Zaleski, M. E. Zamora, O. A. Marcos-Contreras, P. M. Glassman, I. Johnston, E. D. Hood, T. Shuvaeva, J. V. Gregory, , J. S. Brenner

This paper identifies nanoparticle supramolecular organization as a predictor of neutrophil uptake in inflamed lungs, demonstrating diagnostic and therapeutic potential for acute lung inflammation.

bioRxiv · Apr 15, 2020 · PreprintBioengineering