Author

S. Omo-Lamai

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 2 Pharmacology & Toxicology· 2

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 4 Approach:experimental assay· 4 Organism:mouse· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:development & morphogenesis· 1 Research Focus:host-pathogen & immune response· 1 Approach:mechanistic / dynamical model· 1

Frequent Co-Authors

J. S. Brenner· 4 shared J. W. Myerson· 4 shared O. A. Marcos-Contreras· 4 shared J. Nong· 3 shared M. E. Zamora· 3 shared D. Weissman· 2 shared E. Arguiri· 2 shared J. Wu· 2 shared

Activity by Year

2022-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 41 mutual co-author links

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4 shared papersBioengineering

J. S. Brenner

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Author profile →

4 papers

Recent·Most cited

A combination of physicochemical tropism and affinity moiety targeting of lipid nanoparticles enhances organ targeting

M. E. Zamora, S. Omo-Lamai, M. N. Patel, J. Wu, E. Arguiri, V. Muzykantov, J. W. Myerson, O. A. Marcos-Contreras, J. S. Brenner

This paper combines affinity moiety targeting and physicochemical tropism in lipid nanoparticles to enhance organ targeting, showing improved specificity and uptake in lungs and brain.

bioRxiv · Nov 21, 2023Bioengineering

Physicochemical Targeting of Lipid Nanoparticles to the Lungs Induces Clotting: Mechanisms and Solutions

S. Omo-Lamai, M. E. Zamora, M. N. Patel, J. Wu, J. Nong, Z. Wang, A. Peshkova, L. S. Chase, E.-O. Essien, V. Muzykantov, O. A. Marcos-Contreras, J. W. Myerson, J. S. Brenner

This study identifies thrombosis as a risk of lung-targeted cationic lipid nanoparticles and proposes solutions to mitigate clotting without compromising targeting.

bioRxiv · Jul 21, 2023Bioengineering

Targeting lipid nanoparticles to the blood brain barrier to ameliorate acute ischemic stroke

J. Nong, P. M. Glassman, S. Reyes-Esteves, H. C. Descamps, V. V. Shuvaev, R. Y. Kiseleva, T. E. Papp, M.-G. Alameh, Y. K. Tam, B. L. Mui, S. Omo-Lamai, M. E. Zamora, T. Shuvaeva, E. Arguiri, C. A. Thaiss, , O. A. Marcos-Contreras

This paper develops VCAM-targeted lipid nanoparticles to enhance drug delivery to the blood-brain barrier in acute ischemic stroke, reducing infarct volume and mortality.

bioRxiv · Jun 12, 2023Pharmacology & Toxicology

Targeted nanocarriers coopting pulmonary leukocytes for drug delivery to the injured brain

P. M. Glassman, J. Nong, J. W. Myerson, V. Zuluaga-Ramirez, A. Rodriguez-Garcia, A. Mukalel, S. Omo-Lamai, L. R. Walsh, R. Y. Kiseleva, C. H. Villa, C. F. Greineder, S. E. Kasner, D. Weissman, M. J. Mitchell, S. Muro, , O. A. Marcos-Contreras

This paper demonstrates a strategy for targeted drug delivery to the injured brain by loading drugs onto pulmonary leukocytes using ICAM-targeting nanocarriers, showing increased brain uptake and therapeutic effect in a mouse model.

bioRxiv · Feb 4, 2022 · PreprintPharmacology & Toxicology