Targeting lipid nanoparticles to the blood brain barrier to ameliorate acute ischemic stroke
J. Nong, P. M. Glassman, S. Reyes-Esteves, H. C. Descamps, V. V. Shuvaev, R. Y. Kiseleva, T. E. Papp, M.-G. Alameh, Y. K. Tam, B. L. Mui, S. Omo-Lamai, M. E. Zamora, T. Shuvaeva, E. Arguiri, C. A. Thaiss, , O. A. Marcos-Contreras
This paper develops VCAM-targeted lipid nanoparticles to enhance drug delivery to the blood-brain barrier in acute ischemic stroke, reducing infarct volume and mortality.
bioRxiv · Jun 12, 2023Pharmacology & Toxicology