Author

M. J. Mitchell

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Bioengineering· 1 Cancer Biology· 1 Immunology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 3 Research Focus:drug response / drug discovery· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:development & morphogenesis· 1

Frequent Co-Authors

A. E. Vaughan· 1 shared A. I. Weiner· 1 shared A. Levchenko· 1 shared A. Mukalel· 1 shared A. Rodriguez-Garcia· 1 shared A. Singhal· 1 shared C. F. Greineder· 1 shared C. H. Villa· 1 shared

Activity by Year

2022-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 12 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

1 shared paperImmunology

A. E. Vaughan

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Vascular Endothelial-derived SPARCL1 Exacerbates Viral Pneumonia Through Pro-Inflammatory Macrophage Activation

G. Zhao, M. E. Gentile, L. Xue, C. V. Cosgriff, A. I. Weiner, S. Adams-Tzivelekidis, J. Wong, X. Li, S. Kass-Gergi, N. P. Holcomb, M. C. Basil, K. M. Steward, J. D. Planer, E. Cantu, J. D. Christi, , A. E. Vaughan

This study identifies SPARCL1 as a pro-inflammatory mediator secreted by endothelial cells that worsens viral pneumonia by promoting macrophage activation and is elevated in severe COVID-19 cases.

Nature Communications · May 18, 2024Peer-reviewedImmunology

Solid tumor growth depends on an intricate equilibrium of malignant cell states

S. R. Torborg, O. Grbovic-Huezo, A. Singhal, M. Holm, K. Wu, X. Han, Y.-J. Ho, C. Haglund, M. J. Mitchell, S. W. Lowe, L. E. Dow, K. L. Pitter, F. J. Sanchez-Rivera, A. Levchenko, T. Tammela

This study identifies a stereotypic organization of pancreatic ductal adenocarcinoma cells based on WNT signaling and Notch ligand interactions, showing that disrupting this equilibrium suppresses tumor growth and metastasis.

bioRxiv · Dec 30, 2023 · PreprintCancer Biology

Towards the Clinical Translation of a Silver Sulfide Nanoparticle Contrast Agent: Large Scale Production with a Highly Parallelized Microfluidic Chip

K. J. Mossburg, S. J. Shepherd, D. Barragan, N. H. O, E. K. Berkow, P. S. N. Maidment, D. N. Rosario Berrios, J. C. Hsu, M. J. Siedlick, S. Yadavali, M. J. Mitchell, D. Issadore, D. P. Cormode

This paper develops a scalable microfluidic method to produce silver sulfide nanoparticles for clinical imaging, showing high-quality output and efficient in vivo clearance.

bioRxiv · Dec 2, 2023Bioengineering

Targeted nanocarriers coopting pulmonary leukocytes for drug delivery to the injured brain

P. M. Glassman, J. Nong, J. W. Myerson, V. Zuluaga-Ramirez, A. Rodriguez-Garcia, A. Mukalel, S. Omo-Lamai, L. R. Walsh, R. Y. Kiseleva, C. H. Villa, C. F. Greineder, S. E. Kasner, D. Weissman, M. J. Mitchell, S. Muro, , O. A. Marcos-Contreras

This paper demonstrates a strategy for targeted drug delivery to the injured brain by loading drugs onto pulmonary leukocytes using ICAM-targeting nanocarriers, showing increased brain uptake and therapeutic effect in a mouse model.

bioRxiv · Feb 4, 2022 · PreprintPharmacology & Toxicology