Author

A. N. Hegazy

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Research Focus:cell type annotation· 4 Research Focus:differential expression· 3 Organism:human· 3 Approach:statistical model· 3 Assay:bulk RNA-seq· 2 Organism:mouse· 2 Assay:scRNA-seq· 2 Research Focus:cell signaling & trafficking· 1

Frequent Co-Authors

C. Peine· 2 shared K. Thurley· 2 shared M. Loehning· 2 shared M. Peine· 2 shared T. Hoefer· 2 shared A. Chomka· 1 shared A. Froehlich· 1 shared A. L. Nguyen· 1 shared

Activity by Year

2017-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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2 shared papersImmunology

C. Peine

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Multimodal profiling of peripheral blood identifies proliferating circulating effector CD4+ T cells as predictors for response to integrin α4β7-blocking therapy in patients with inflammatory bowel disease

V. Horn, C. Cancino, L. Steinheuer, B. Obermayer, K. Fritz, A. L. Nguyen, C. Plattner, D. Boesel, M. Burns, A. R. Schulz, E. Mantzivi, D. Lissner, T. Conrad, M.-F. Mashreghi, E. Sonnenberg, , A. N. Hegazy

bioRxiv · Oct 1, 2023Immunology

Plasticity and lineage commitment of individual Th1 cells are determined by stable T-bet expression quantities

A. N. Hegazy, C. Peine, D. Niesen, I. Panse, Y. Vainshtein, C. Kommer, Q. Zhang, T. M. Brunner, M. Peine, A. Froehlich, N. Ishaque, R. M. Marek, J. J. Zhu, T. Hoefer, M. Loehning

This study shows that T-bet expression levels in Th1 cells determine their plasticity and lineage stability, with virus-induced interferons regulating these states.

bioRxiv · Aug 14, 2022 · PreprintImmunology

High-resolution kinetic gene expression analysis of T helper cell differentiation reveals a STAT-dependent, unique transcriptional program in Th1/2 hybrid cells

P. Burt, M. Peine, C. Peine, Z. Borek, S. Serve, M. Flossdorf, A. N. Hegazy, T. Hoefer, M. Loehning, K. Thurley

This study analyzes the dynamic transcriptome of Th cell differentiation, revealing a unique STAT-dependent transcriptional program in Th1/2 hybrid cells.

bioRxiv · May 13, 2022Immunology

Single cell transcriptomics of regulatory T cells reveals trajectories of tissue adaptation

R. J. Miragaia, T. Gomes, A. Chomka, L. Jardine, A. Riedel, A. N. Hegazy, I. Lindeman, G. Emerton, T. Krausgruber, J. Shields, M. Haniffa, F. Powrie, S. A. Teichmann

The paper uses single-cell RNA-seq to study Treg and Tmem cells in mouse tissues, revealing a lymphoid-to-tissue adaptation trajectory and conserved molecular signals across species.

bioRxiv · Nov 22, 2017Immunology