Author

J. J. Zhu

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 2 Cancer Biology· 2 Ecology· 1 Immunology· 1 Microbiology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 8 Organism:mouse· 4 Approach:statistical model· 4 Research Focus:chromatin & epigenetic regulation· 3 Assay:bulk RNA-seq· 2 Research Focus:cell signaling & trafficking· 2 Research Focus:drug response / drug discovery· 2 Research Focus:ecology & biodiversity· 2

Frequent Co-Authors

A. W. Cheng· 3 shared N. Jillette· 3 shared Q. Zhang· 2 shared A. D. Tran· 1 shared A. Froehlich· 1 shared A. N. Hegazy· 1 shared A. Rai· 1 shared A. Shukla· 1 shared

Activity by Year

2017-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 6 mutual co-author links

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3 shared papersBioengineering

A. W. Cheng

Mutual co-authors in cluster

Author profile →

9 papers

Recent·Most cited

The Treatment of diarrheal mice with Tenebrio Molitor meal

t. t. Liu, Q. l. wang, z. l. wang, j. x. yan, j. j. zhu, h. shen, j. g. wang

This study shows that adding Tenebrio molitor meal to the diet of diarrhea mice improves their health by increasing feed intake, reducing diarrhea rates, and enhancing enzyme activities.

bioRxiv · Dec 21, 2023 · PreprintZoology

Plasticity and lineage commitment of individual Th1 cells are determined by stable T-bet expression quantities

A. N. Hegazy, C. Peine, D. Niesen, I. Panse, Y. Vainshtein, C. Kommer, Q. Zhang, T. M. Brunner, M. Peine, A. Froehlich, N. Ishaque, R. M. Marek, J. J. Zhu, T. Hoefer, M. Loehning

This study shows that T-bet expression levels in Th1 cells determine their plasticity and lineage stability, with virus-induced interferons regulating these states.

bioRxiv · Aug 14, 2022 · PreprintImmunology

Targeted directional kilobase sequence insertion by combining prime editing with recombinases or integrases

N. Jillette, J. J. Zhu, A. W. Cheng

This paper introduces PRIMAS, a method combining prime editing with recombinases/integrases to insert kilobase sequences directionally into genomes.

bioRxiv · May 25, 2022 · PreprintBioengineering

Local recruitment of DNA repair proteins enhances CRISPR-ssODN-HDR editing

N. Jillette, J. J. Zhu, A. W. Cheng

This study enhances CRISPR-ssODN-HDR editing by recruiting DNA repair proteins to Cas9 cut sites using two strategies, increasing precise edits.

bioRxiv · Apr 13, 2022 · PreprintBioengineering

C11orf95-RELA Reprograms 3D Epigenome in Supratentorial Ependymoma

J. J. Zhu, N. Jillette, X.-N. Li, A. W. Cheng, C. C. Lau

This study investigates how the C11orf95-RELA fusion protein reprograms the 3D epigenome in supratentorial ependymoma, revealing its role in chromatin state modulation and transcriptional reprogramming.

bioRxiv · Jun 4, 2020Cancer Biology

Depletion of nuclear pore protein NUP210 suppresses metastasis through heterochromatin-mediated disruption of tumor cell mechanical response

R. Amin, A. Shukla, J. J. Zhu, S. Kim, P. Wang, S. Z. Tian, A. D. Tran, D. Paul, S. D. Cappell, S. Burkett, H. Liu, M. P. Lee, M. J. Kruhlak, J. E. Dwyer, R. M. Simpson, , K. W. Hunter

This study identifies NUP210 as a metastasis susceptibility gene in ER+ breast cancer, showing its role in mechanosensation through heterochromatin-mediated disruption of mechanotransduction.

bioRxiv · Feb 5, 2020Cancer Biology

Development of a highly effective African swine fever virus vaccine by deletion of the I177L gene results in sterile immunity against the current epidemic Eurasia strain

M. V. Borca, E. Ramirez-Medina, E. B. SiIva, E. A. Vuono, A. Rai, S. Pruitt, L. G. Holinka, L. Velazquez-Salinas, J. J. Zhu, D. P. Gladue

bioRxiv · Dec 2, 2019Microbiology

Selective Activation of TASK-3-containing K+ Channels Reveals Their Therapeutic Potentials in Analgesia

P. Liao, Y. Qiu, Y. Mo, J. Fu, Z. Song, L. Huang, S. Bai, Y. Wang, J. J. Zhu, F. Tian, Z. Chen, N. Pan, E. Y. Sun, L. Yang, X. Lan, , H. Yang

The paper identifies CHET3, a selective TASK-3 activator, and demonstrates its analgesic effects in pain models, highlighting TASK-3 as a novel non-opioid analgesic target.

bioRxiv · Jun 28, 2019 · PreprintPharmacology & Toxicology

Assessment of the World Largest Afforestation Program: Success, Failure, and Future Directions

J. J. Zhu, X. Zheng, G.G. Wang, B.F. Wu, S.R. Liu, C.Z. Yan, Y. Li, Y.R. Sun, Q.L. Yan, Y. Zeng, S.L. Lu, X. F. Li, L.N. Song, Z. B. Hu, K. Yang, , Aaron M. Ellison

The paper assesses the Three-North Afforestation Program's first 30 years, finding increased forest area but declining quality, limited desertification reduction, and low shelterbelt coverage.

bioRxiv · Feb 3, 2017 · PreprintEcology