T. Krausgruber

Nuclear receptor corepressor 1 controls regulatory T cell subset differentiation and effector function

This study shows NCOR1 regulates Treg cell differentiation and suppressive function by maintaining transcriptional integrity in both naive and effector states.

HDAC1 controls the generation and maintenance of effector-like CD8+ T cells during chronic viral infection

This study shows HDAC1 is essential for generating and maintaining CX3CR1+ effector-like T cells during chronic viral infection, which helps control viral load.

Single-cell profiling uncovers regulatory programs of pathogenic Th2 cells in allergic asthma

This study uses scRNA-seq to identify two distinct subsets of pathogenic Th2 cells in allergic asthma and establishes an in vitro model to study their regulation.

Multi-organ single-cell RNA-sequencing reveals early hyperglycaemia responses that converge on fibroblast dysregulation

This study uses scRNA-seq to analyze early hyperglycaemia responses in multiple organs of a mouse model, identifying conserved and organ-specific transcriptional changes linked to diabetes complications.

STAT5 Gain-of-Function Variants Promote Precursor T-Cell Receptor Activation to Drive T-Cell Acute Lymphoblastic Leukemia

This study identifies STAT5 gain-of-function mutations as drivers of T-ALL by promoting pre-TCR signaling and shows therapeutic targeting potential with STAT3/5 or ZAP70 inhibitors.

STAT3 promotes melanoma metastasis by CEBP-induced repression of the MITF pigmentation pathway

This study shows that STAT3 promotes melanoma metastasis by repressing the MITF pigmentation pathway through CEBP induction.

Chromatin mapping and single-cell immune profiling define the temporal dynamics of ibrutinib drug response in chronic lymphocytic leukemia

This study maps chromatin changes and single-cell immune profiles during ibrutinib treatment in CLL, identifying a shared regulatory program and patient-specific response dynamics.

Single cell transcriptomics of regulatory T cells reveals trajectories of tissue adaptation

The paper uses single-cell RNA-seq to study Treg and Tmem cells in mouse tissues, revealing a lymphoid-to-tissue adaptation trajectory and conserved molecular signals across species.