Author

A. N. Murtha

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:bacteria (other)· 2 Research Focus:host-pathogen & immune response· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:drug response / drug discovery· 1 Approach:genetic perturbation / CRISPR· 1

Frequent Co-Authors

M. I. Kazi· 2 shared T. Doerr· 2 shared C. Fihn· 1 shared E. E. Carlson· 1 shared E. Kim· 1 shared F. Cava· 1 shared F. V. Torres· 1 shared J. M. Boll· 1 shared

Activity by Year

2021-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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2 shared papersMicrobiology

M. I. Kazi

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3 papers

Recent·Most cited

Multiple resistance factors collectively promote inoculum-dependent dynamic survival during antimicrobial peptide exposure in Enterobacter cloacae

A. N. Murtha, M. I. Kazi, E. Kim, K. M. Rosch, F. V. Torres, T. Doerr

This study identifies three genetic factors in Enterobacter cloacae that collectively contribute to resistance against the antimicrobial peptide cecropin B, showing inoculum-dependent survival heterogeneity.

bioRxiv · Mar 3, 2024 · PreprintMicrobiology

High-level carbapenem tolerance requires antibiotic-induced outer membrane modifications.

A. N. Murtha, M. I. Kazi, R. D. Schargel, T. Cross, C. Fihn, E. E. Carlson, J. M. Boll, T. Dörr

This paper identifies PhoPQ-mediated LPS modifications as a mechanism for carbapenem tolerance in Enterobacterales, showing that antibiotic-induced outer membrane changes enhance survival.

bioRxiv · Sep 25, 2021Microbiology

Class A Penicillin-Binding Protein-mediated cell wall synthesis promotes structural integrity during peptidoglycan endopeptidase insufficiency

S. G. Murphy, A. N. Murtha, Z. Zhao, L. Alvarez, P. Diebold, J.-H. Shin, M. S. VanNieuwenhze, F. Cava, T. Doerr

This study investigates the role of endopeptidases and class A PBPs in PG synthesis and structural integrity in V. cholerae, showing that aPBPs can compensate for EP insufficiency.

mBio · Apr 27, 2021Peer-reviewedMicrobiology