Author

J.-H. Shin

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 9 Biochemistry· 1 Plant Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 11 Organism:bacteria (other)· 5 Research Focus:host-pathogen & immune response· 4 Research Focus:cell signaling & trafficking· 3 Organism:human· 3 Assay:metagenomics· 3 Assay:proteomics· 3 Organism:plant (other)· 2

Frequent Co-Authors

T. Doerr· 4 shared A. Sulpizio· 2 shared B. Ransegnola· 2 shared F. Cava· 2 shared I. Onyekwere· 2 shared L. Alvarez· 2 shared M. VanNieuwenhze· 2 shared S. G. Murphy· 2 shared

Activity by Year

2018-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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4 shared papersMicrobiology

T. Doerr

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Author profile →

11 papers

Recent·Most cited

Genetic and transcriptomic analysis of hyphal constriction based on a novel assay method in the rice blast fungus

E. Cho, S. H. Lee, M. Jeong, S. Mandal, S.-Y. Park, S. W. Nam, D. G. Byeun, J. K. Choi, Y.-H. Lee, J.-H. Shin, J. Jeon

The paper introduces an in vitro assay to study hyphal constriction in Magnaporthe oryzae, identifying transcriptional changes and a potential histone modification role in this process.

bioRxiv · Jun 14, 2023 · PreprintMicrobiology

Mechanical stimuli activate gene expression via a cell envelope stress sensing pathway

C. E. Harper, W. Zhang, J.-H. Shin, E. van Wijngaarden, E. Chou, J. Lee, Z. Wang, T. Doerr, P. Chen, C. J. Hernandez

This study shows mechanical stress in bacterial cell envelopes activates the VxrAB two-component system, promoting cell wall synthesis and homeostasis.

bioRxiv · Sep 25, 2022Microbiology

The effect of treatment of auxin producing bacterial culture supernatant in combination with organic and inorganic fertilizers

S. Park, J.-H. Shin

This study combines auxin-producing bacterial culture supernatant with organic and inorganic fertilizers to enhance red kohlrabi growth, showing improved photosynthetic efficiency and photoprotective mechanisms.

bioRxiv · Jan 31, 2022 · PreprintPlant Biology

Class A Penicillin-Binding Protein-mediated cell wall synthesis promotes structural integrity during peptidoglycan endopeptidase insufficiency

S. G. Murphy, A. N. Murtha, Z. Zhao, L. Alvarez, P. Diebold, J.-H. Shin, M. S. VanNieuwenhze, F. Cava, T. Doerr

This study investigates the role of endopeptidases and class A PBPs in PG synthesis and structural integrity in V. cholerae, showing that aPBPs can compensate for EP insufficiency.

mBio · Apr 27, 2021Peer-reviewedMicrobiology

CTCF-mediated Genomic Effects of BART Region on Epstein-Barr Virus Chromatin 3D Structure in Gastric Carcinoma Cells

K.-D. Kim, S. Cho, T. Kim, S. Huh, L. Kim, H. Tanizawa, J.-H. Shin, T. Kanda, K. J. Won, P. M. Lieberman, H. Cho, H. Kang

This study investigates how CTCF binding at the BARTp site regulates EBV 3D genome structure and gene expression in EBVaGC cells, showing its role in DNA looping and viral infectivity.

bioRxiv · Dec 3, 2020 · PreprintMicrobiology

A multifaceted cellular damage repair and prevention pathway promotes high level tolerance to β-lactam antibiotics

J.-H. Shin, D. Choe, B. Ransegnola, H.-R. Hong, I. Onyekwere, T. Cross, Q. Shi, B.-K. Cho, L. F. Westblade, I. Brito, T. Doerr

This study shows that the VxrAB system in Vibrio cholerae reduces β-lactam antibiotic toxicity by managing iron levels and oxidative damage, enhancing bacterial tolerance.

bioRxiv · Aug 6, 2020Microbiology

Although host-related factors are important for the formation of gut microbiota, environmental factors cannot be ignored

Y. Jung, D. Kerfahi, H. Q. Pham, H. Son, J. C. Ibal, M.-K. Park, Y.-J. Park, C. E. Park, S.-D. Choi, Y. Jo, M.-C. Kim, M. J. Kim, G. U. Kang, H. W. Jo, H. Yun, , J.-H. Shin

This study compares host-related factors and environmental factors in shaping gut microbiota using fecal samples from naval trainees and healthy individuals, finding host factors more influential.

bioRxiv · Feb 3, 2020 · PreprintMicrobiology

Structural basis of peptidoglycan endopeptidase regulation

J.-H. Shin, A. Sulpizio, A. Kelley, L. Alvarez, S. Murphy, F. Cava, Y. Mao, M. A. Saper, T. Doerr

This study solves the crystal structure of ShyA, a peptidoglycan endopeptidase, revealing a regulatory mechanism involving conformational changes that activate its catalytic activity.

bioRxiv · Nov 17, 2019Microbiology

Protein polyglutamylation catalyzed by the bacterial Calmodulin-dependent pseudokinase SidJ

A. Sulpizio, M. E. Minelli, M. Wan, P. D. Burrowes, X. Wu, E. J. Sanford, J.-H. Shin, B. Williams, M. L. Goldberg, M. B. Smolka, Y. Mao

This study identifies SidJ as a bacterial pseudokinase that catalyzes polyglutamylation of SdeA, a Legionella effector, in a CaM-dependent manner, suppressing ADP-ribosylation.

bioRxiv · Aug 20, 2019Biochemistry

Spheroplast-mediated carbapenem tolerance in Gram-negative pathogens

T. Cross, B. Ransegnola, J.-H. Shin, A. Weaver, K. Fauntleroy, M. VanNieuwenhze, L. Westblade, T. Dörr

This study shows that several Gram-negative pathogens exhibit carbapenem tolerance through cell wall-deficient spheroplasts, which can recover upon antibiotic removal.

bioRxiv · Mar 15, 2019Microbiology

Genetic determinants of penicillin tolerance in Vibrio cholerae

A. I. Weaver, S. G. Murphy, B. Umans, S. Tallavajhala, I. Onyekwere, S. Wittels, J.-H. Shin, M. VanNieuwenhze, M. K. Waldor, T. Dörr

This study identifies genetic factors in Vibrio cholerae that contribute to penicillin tolerance and post-antibiotic recovery.

bioRxiv · Jun 4, 2018Microbiology