Author

E. E. Carlson

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 8 Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 8 Organism:bacteria (other)· 7 Research Focus:drug response / drug discovery· 4 Research Focus:cell type annotation· 3 Assay:proteomics· 3 Approach:genetic perturbation / CRISPR· 2 Research Focus:host-pathogen & immune response· 2 Research Focus:cell signaling & trafficking· 1

Frequent Co-Authors

C. Fihn· 2 shared D. B. Kearns· 2 shared S. E. Jones· 2 shared A. Espinasse· 1 shared A. Gilbertsen· 1 shared A. J. Perez· 1 shared A. N. Murtha· 1 shared A. R. Johnson· 1 shared

Activity by Year

2018-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 6 mutual co-author links

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2 shared papersMicrobiology

C. Fihn

Mutual co-authors in cluster

Author profile →

9 papers

Recent·Most cited

kinact/KI Value Determination for Penicillin-Binding Proteins in Live Cells

J. D. Shirley, K. M. Nauta, J. R. Gillingham, S. Diwakar, E. E. Carlson

The paper develops a whole-cell assay to measure kinact/KI values for PBPs in Streptococcus pneumoniae, showing results consistent with in vitro data and supporting its validity as an in vivo method.

bioRxiv · May 5, 2024 · PreprintBiochemistry

Evaluation of Expanded 2-Aminobenzothiazole Library for Inhibition of Pseudomonas aeruginosa Virulence Phenotypes

C. Fihn, H. Lembke, J. Gaulin, P. Bouchard, A. R. Villarreal, M. R. Penningroth, K. Crone, G. Vogt, A. Gilbertsen, Y. Ayotte, L. CouthinodeOliveira, M. Serrano-Wu, N. Drouin, D. Hung, R. C. Hunter, E. E. Carlson

The paper evaluates a library of 2-aminobenzothiazole compounds targeting the CA domain of histidine kinases, finding they reduce virulence in Pseudomonas aeruginosa.

bioRxiv · May 2, 2023 · PreprintMicrobiology

Penicillin-binding protein redundancy in Bacillus subtilis enables growth during alkaline shock

S. L. Mitchell, D. B. Kearns, E. E. Carlson

This study shows that Bacillus subtilis uses redundant penicillin-binding proteins (PBPs) to adapt to alkaline stress, with some PBPs becoming more active or modified during alkaline shock.

bioRxiv · Mar 20, 2023 · PreprintMicrobiology

Cationic Polymers Enable Internalization of Negatively Charged Chemical Probe into Bacteria

H. K. Lembke, A. Espinasse, M. G. Hanson, C. J. Grimme, Z. Tan, T. M. Reineke, E. E. Carlson

This study evaluates cationic polymers for delivering negatively charged ATP-based probes into bacteria, finding micellar polymers more effective than linear ones without causing significant toxicity.

bioRxiv · Mar 19, 2023 · PreprintMicrobiology

High-level carbapenem tolerance requires antibiotic-induced outer membrane modifications.

A. N. Murtha, M. I. Kazi, R. D. Schargel, T. Cross, C. Fihn, E. E. Carlson, J. M. Boll, T. Dörr

This paper identifies PhoPQ-mediated LPS modifications as a mechanism for carbapenem tolerance in Enterobacterales, showing that antibiotic-induced outer membrane changes enhance survival.

bioRxiv · Sep 25, 2021Microbiology

Organization of Peptidoglycan Synthesis in Nodes and Separate Rings at Different Stages of Cell Division of Streptococcus pneumoniae

A. J. Perez, M. J. Boersma, K. E. Bruce, M. M. Lamanna, S. L. Shaw, H.-C. T. Tsui, A. Taguchi, E. E. Carlson, M. S. VanNieuwenhze, M. E. Winkler

This paper investigates the spatial organization of peptidoglycan synthesis in Streptococcus pneumoniae during cell division, revealing distinct rings and nodes of transpeptidase activity and PBP localization.

bioRxiv · Sep 27, 2020Microbiology

Harnessing β-Lactam Antibiotics for Illumination of the Activity of Penicillin-Binding Proteins in Bacillus subtilis

S. Sharifzadeh, F. Dempwolff, D. B. Kearns, E. E. Carlson

This study identifies β-lactam antibiotics that selectively inhibit specific penicillin-binding proteins (PBPs) in Bacillus subtilis and reveals PBP3 activity patterns using activity-based probes.

bioRxiv · Dec 19, 2019Microbiology

Silencing cryptic specialized metabolism in Streptomyces by the nucleoid-associated protein Lsr2

E. J. Gehrke, X. Zhang, S. M. Pimentel-Elardo, A. R. Johnson, C. A. Rees, S. E. Jones, Hindra, S. S. Gehrke, S. Turvey, S. Boursalie, J. E. Hill, E. E. Carlson, J. R. Nodwell, M. A. Elliot

This study shows that Lsr2 represses specialized metabolic gene clusters in Streptomyces, revealing its role in silencing cryptic metabolism and controlling the production of secondary metabolites.

bioRxiv · Apr 22, 2019Microbiology

Streptomyces volatile compounds influence exploration and microbial community dynamics by altering iron availability

S. E. Jones, C. A. Pham, J. McKillip, M. Zambri, E. E. Carlson, M. Elliot

The paper shows that TMA, a Streptomyces VOC, alters iron availability by increasing pH, which affects microbial growth and community dynamics.

bioRxiv · Aug 21, 2018Microbiology