Author

A. O'Donoghue

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Biochemistry· 2 Microbiology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 3 Assay:proteomics· 2 Organism:bacteria (other)· 1 Organism:human· 1 Organism:non-human primate· 1

Frequent Co-Authors

A. Drelich· 2 shared C.-T. Tseng· 2 shared D. Skinner· 2 shared L. Li· 2 shared P. Fajtova· 2 shared A. Aggarwal· 1 shared A. Ashhurst· 1 shared A. E. Clark· 1 shared

Activity by Year

2020-2020 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersBiochemistry

A. Drelich

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Potent in vitro anti-SARS-CoV-2 activity by gallinamide A and analogues via inhibition of cathepsin L

A. Ashhurst, A. Tang, P. Fajtova, M. Yoon, A. Aggarwal, A. Stoye, M. Larance, L. Beretta, A. Drelich, D. Skinner, L. Li, T. Meek, J. McKerrow, V. Hook, C.-T. Tseng, , R. J. Payne

bioRxiv · Dec 23, 2020 · PreprintBiochemistry

A cysteine protease inhibitor blocks SARS-CoV-2 infection of human and monkey cells

D. Mellott, C.-T. Tseng, A. Drelich, P. Fajtova, B. C. Chenna, D. Kostomiris, J. C. Hsu, J. Zhu, Z. Taylor, V. Tat, A. Katzfuss, L. Li, M. A. Giardini, D. Skinner, K. Hirata, , J. H. McKerrow

This paper shows that K777, a cysteine protease inhibitor, blocks SARS-CoV-2 infection by inhibiting host cathepsin L, which is required for spike protein processing, with nanomolar efficacy in several cell lines.

bioRxiv · Oct 23, 2020 · PreprintBiochemistry

Role of Inflammasome-independent Activation of IL-1β by the Pseudomonas aeruginosa Protease LasB

J. Sun, D. LaRock, E. Skowronski, J. M. Kimmey, J. Olson, Z. Jiang, A. O'Donoghue, V. Nizet, C. LaRock

This study identifies that the Pseudomonas aeruginosa protease LasB directly activates IL-1β independently of inflammasomes, contributing to lung inflammation and pathology during infection.

bioRxiv · May 18, 2020 · PreprintMicrobiology