Author

A. P. Adam

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 4

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Research Focus:cell signaling & trafficking· 2 Approach:experimental assay· 2 Organism:human· 2 Organism:mouse· 2 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:differential expression· 1

Frequent Co-Authors

N. Martino· 3 shared L. Tomaszek· 2 shared P. A. Vincent· 2 shared R. Bossardi Ramos· 2 shared S. Lu· 2 shared A. Jaitovich· 1 shared D. Chuy· 1 shared D. Jourd'heuil· 1 shared

Activity by Year

2020-2022 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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3 shared papersCell Biology

N. Martino

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Author profile →

4 papers

Recent·Most cited

Shock drives a highly coordinated transcriptional and DNA methylation response in the endothelium

R. B. Ramos, N. Martino, D. S. Chuy, S. Lu, U. Balasubramanian, I. Di John Portela, P. A. Vincent, A. P. Adam

The paper investigates how shock-induced IL-6 signaling alters DNA methylation and transcription in endothelial cells, revealing a mechanism for sustained vascular dysfunction post-shock.

bioRxiv · Aug 1, 2022 · PreprintCell Biology

SOCS3 limits endotoxin-induced endothelial dysfunction by blocking a required autocrine interleukin 6 signal in human umbilical vein endothelial cells

N. Martino, R. Bossardi Ramos, D. Chuy, L. Tomaszek, A. P. Adam

The paper shows that sIL-6R enhances LPS-induced endothelial dysfunction by activating STAT1/STAT3, which is blocked by SOCS3 overexpression or JAK inhibition.

bioRxiv · Apr 25, 2022 · PreprintCell Biology

DMT1 bridges endosomes and mitochondria to modulate mitochondrial iron translocation

J. Barra, I. Crosbourne, L. Wang, R. Bossardi-Ramos, F. Jourd'heuil, I. Nelson, A. P. Adam, D. T. Corr, D. Jourd'heuil, M. Barroso

This study shows DMT1 modulates mitochondrial iron translocation in invasive breast cancer cells by bridging endosomes and mitochondria, affecting iron levels and mitochondrial function.

bioRxiv · Apr 14, 2022Cell Biology

Endothelial SOCS3 maintains homeostasis and promotes survival in endotoxemic mice

N. Martino, R. Bossardi Ramos, S. Lu, K. Leyden, L. Tomaszek, S. Sadhu, G. Fredman, A. Jaitovich, P. A. Vincent, A. P. Adam

This paper shows that endothelial SOCS3 prevents shock-induced organ failure by inhibiting IL-6 signaling and maintaining vascular barrier function.

bioRxiv · Dec 28, 2020Cell Biology