Author

S. Sadhu

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 3 Microbiology· 2 Cell Biology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 7 Research Focus:host-pathogen & immune response· 7 Organism:mouse· 6 Research Focus:cell signaling & trafficking· 3 Research Focus:cell type annotation· 3 Research Focus:differential expression· 2 Assay:metabolomics· 2 Assay:proteomics· 2

Frequent Co-Authors

A. Awasthi· 4 shared G. Fredman· 3 shared Z. A. Rizvi· 3 shared A. K. Pandey· 2 shared C. Decker· 2 shared K. C. MacNamara· 2 shared M. Marinello· 2 shared M. R. Tripathy· 2 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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4 shared papersMicrobiology

A. Awasthi

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

VapC12 ribonuclease toxin modulates host immune response during Mycobacterium tuberculosis infection

S. Tyagi, S. Sadhu, T. Sharma, A. Paul, M. Pandey, V. Nain, D. Rathore, S. Chatterjee, A. Awasthi, A. K. Pandey

This study shows that the VapC12 toxin in Mycobacterium tuberculosis modulates host immune responses, promoting pathogen survival by altering T-cell and neutrophil responses.

bioRxiv · Aug 24, 2023 · PreprintMicrobiology

The Resolvin D2-GPR18 Axis Enhances Bone Marrow Function and Limits Hepatic Fibrosis in Aging

H. Fitzgerald, J. L. Bonin, S. Sadhu, M. Lipscomb, N. Biswas, C. Decker, M. Nabage, R. Bossardi, M. Marinello, A. Hebe Mena, K. Gilliard, M. Spite, A. Adam, K. C. MacNamara, G. Fredman

This study shows that RvD2-GPR18 signaling reduces hepatic fibrosis and steatosis in aging by enhancing bone marrow function and macrophage populations.

bioRxiv · Jan 5, 2023 · PreprintPhysiology

Prophylactic treatment of Glycyrrhiza glabra mitigates COVID-19 pathology through inhibition of pro-inflammatory cytokines in the hamster model and NETosis.

Z. A. Rizvi, P. Babele, S. Sadhu, U. Madan, M. R. Tripathy, S. Goswami, S. Mani, S. Kumar, A. Awasthi, M. Dikshit

This study shows that Glycyrrhiza glabra extract reduces inflammation and lung damage in hamsters infected with SARS-CoV-2 by lowering pro-inflammatory cytokines and NETosis.

bioRxiv · May 16, 2022Immunology

SARS-CoV-2 and its variants, but not Omicron, induces thymic atrophy and impaired T cell development

Z. A. Rizvi, S. Sadhu, J. Dandotiya, A. Binayke, P. Sharma, V. Singh, V. Das, R. Khatri, R. Kumar, S. Samal, M. Kalia, A. Awasthi

This study shows SARS-CoV-2 and its variants cause thymic atrophy and impair T cell development, with Omicron having a lesser effect than Delta.

bioRxiv · Apr 7, 2022 · PreprintImmunology

Sub-lethal radiation-induced senescence impairs resolution programs and drives cardiovascular inflammation

S. Sadhu, C. Decker, B. E. Sansbury, M. Marinello, A. Seyfried, J. Howard, M. Mori, Z. Hosseini, T. Arunachalam, A. V. Finn, J. M. Lamar, D. Jourd'heuil, L. Guo, K. C. MacNamara, M. Spite, G. Fredman

This study shows sub-lethal radiation induces macrophage senescence, impairing efferocytosis and promoting cardiovascular inflammation, with RvD1 treatment reversing these effects.

bioRxiv · May 19, 2021Immunology

Immunological and cardio-vascular pathologies associated with SARS-CoV-2 infection in golden syrian hamster

Z. A. Rizvi, R. Dalal, S. Sadhu, Y. Kumar, T. Shrivastava, S. K. Gupta, S. Aggarwal, M. R. Tripathy, A. K. Yadav, G. R. Medigeshi, A. K. Pandey, S. Samal, S. Asthana, A. Awasthi

This study shows that SARS-CoV-2 infection in golden Syrian hamsters causes lung and cardiovascular pathologies similar to human COVID-19, suggesting GSH as a model for studying long-term effects.

bioRxiv · Jan 11, 2021Microbiology

Endothelial SOCS3 maintains homeostasis and promotes survival in endotoxemic mice

N. Martino, R. Bossardi Ramos, S. Lu, K. Leyden, L. Tomaszek, S. Sadhu, G. Fredman, A. Jaitovich, P. A. Vincent, A. P. Adam

This paper shows that endothelial SOCS3 prevents shock-induced organ failure by inhibiting IL-6 signaling and maintaining vascular barrier function.

bioRxiv · Dec 28, 2020Cell Biology