Author

A. Jaitovich

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2 Physiology· 2 Biochemistry· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Organism:mouse· 5 Research Focus:cell type annotation· 4 Research Focus:differential expression· 3 Assay:bulk RNA-seq· 2 Research Focus:metabolism & bioenergetics· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:chromatin & epigenetic regulation· 1

Frequent Co-Authors

J. Balnis· 5 shared C. G. Lee· 2 shared C. Mathai· 2 shared C. Vincent· 2 shared D. Jourd'heuil· 2 shared H. A. Singer· 2 shared J. J. Coon· 2 shared K. A. Overmyer· 2 shared

Activity by Year

2020-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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5 shared papersPhysiology

J. Balnis

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Nuclear cytoglobin associates with HMGB2 and regulates DNA damage and genome-wide transcriptional output in the vasculature

C. Mathai, F. Jourd'heuil, L. G. C. Pham, K. Gilliard, D. Howard, J. Balnis, A. Jaitovich, S. Chittur, M. Riley, R. Peredo-Wende, A. Ibrahim, S. Shin, M. Barroso, J. Barra, E. Shishkova, , D. Jourd'heuil

This study identifies nuclear cytoglobin's role in regulating DNA damage and transcriptional output in vascular smooth muscle cells through its interaction with HMGB2.

bioRxiv · May 10, 2023Cell Biology

A role for cytoglobin in regulating intracellular hydrogen peroxide and redox signals in the vasculature

C. Mathai, F. L. Jourd'heuil, L. G. C. Pham, K. Gilliard, J. Balnis, A. Jen, K. A. Overmyer, J. J. Coon, A. Jaitovich, B. Boivin, D. Jourd'heuil

This study shows cytoglobin regulates intracellular hydrogen peroxide and redox signals by reducing hyperoxidation of peroxiredoxins and facilitating Hyper7 reduction, independent of heme-based hydrogen peroxide reactions.

bioRxiv · Mar 31, 2023 · PreprintBiochemistry

Severe COVID-19 shares a common neutrophil activation signature with other acute inflammatory states

L. F. Schimke, A. H. Marques, G. C. Baiocchi, C. A. Prado, D. L. Fonseca, P. P. Freire, D. R. Placa, I. S. Filgueira, R. C. Salgado, G. Jansen-Marques, A. E. Oliveira, J. P. S. Peron, G. Cabral Miranda, J. A. M. Barbuto, N. O. S. Camara, , O. C. Marques

This study identifies a shared neutrophil activation signature between severe COVID-19 and other acute inflammatory conditions, suggesting common therapeutic targets.

bioRxiv · Jul 30, 2021Immunology

Dysregulated myogenesis and autophagy in genetically induced pulmonary emphysema

J. Balnis, L. A. Drake, D. V. Singer, C. Vincent, T. C. Korponay, J. M. D'Armiento, C. G. Lee, J. A. Elias, H. A. Singer, A. Jaitovich

This study identifies dysregulated myogenesis and autophagy in COPD-induced muscle dysfunction and shows that autophagy stimulation can improve satellite cell function and myogenesis.

bioRxiv · Jul 8, 2021 · PreprintPhysiology

Succinate Dehydrogenase (SDH)-subunit C regulates muscle oxygen consumption and fatigability in an animal model of pulmonary emphysema.

J. Balnis, L. Drake, C. Vincent, T. C. Korponay, D. Singer, D. Lacomis, C. G. Lee, J. Elias, H. A. Singer, A. Jaitovich

The paper investigates the role of SDH subunit C in muscle oxygen consumption and fatigability in an animal model of pulmonary emphysema, finding that SDHC regulates respiration and fiber type composition.

bioRxiv · Jan 22, 2021Physiology

Endothelial SOCS3 maintains homeostasis and promotes survival in endotoxemic mice

N. Martino, R. Bossardi Ramos, S. Lu, K. Leyden, L. Tomaszek, S. Sadhu, G. Fredman, A. Jaitovich, P. A. Vincent, A. P. Adam

This paper shows that endothelial SOCS3 prevents shock-induced organ failure by inhibiting IL-6 signaling and maintaining vascular barrier function.

bioRxiv · Dec 28, 2020Cell Biology