Author

N. Martino

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 3 Bioengineering· 1 Biophysics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:cell type annotation· 3 Assay:bulk RNA-seq· 2 Research Focus:cell-cell communication· 2 Research Focus:clustering· 2 Research Focus:differential expression· 2 Organism:human· 2 Organism:mouse· 2

Frequent Co-Authors

A. P. Adam· 3 shared L. Tomaszek· 2 shared P. A. Vincent· 2 shared R. Bossardi Ramos· 2 shared S. Forward· 2 shared S. Lu· 2 shared A. C. Liapis· 1 shared A. Jaitovich· 1 shared

Activity by Year

2018-2022 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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3 shared papersCell Biology

A. P. Adam

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Shock drives a highly coordinated transcriptional and DNA methylation response in the endothelium

R. B. Ramos, N. Martino, D. S. Chuy, S. Lu, U. Balasubramanian, I. Di John Portela, P. A. Vincent, A. P. Adam

The paper investigates how shock-induced IL-6 signaling alters DNA methylation and transcription in endothelial cells, revealing a mechanism for sustained vascular dysfunction post-shock.

bioRxiv · Aug 1, 2022 · PreprintCell Biology

Laser particle barcoding for multi-pass high-dimensional flow cytometry

S. J. Kwok, S. Forward, M. D. Fahlberg, S. Cosgriff, S. H. Lee, G. Abbott, H. Zhu, N. H. Minasian, A. S. Vote, N. Martino, S. H. Yun

This paper introduces multi-pass flow cytometry using laser particle barcoding to enable high-dimensional single-cell analysis with reduced spectral overlap and simplified panel design.

bioRxiv · Jun 3, 2022 · PreprintBioengineering

SOCS3 limits endotoxin-induced endothelial dysfunction by blocking a required autocrine interleukin 6 signal in human umbilical vein endothelial cells

N. Martino, R. Bossardi Ramos, D. Chuy, L. Tomaszek, A. P. Adam

The paper shows that sIL-6R enhances LPS-induced endothelial dysfunction by activating STAT1/STAT3, which is blocked by SOCS3 overexpression or JAK inhibition.

bioRxiv · Apr 25, 2022 · PreprintCell Biology

Endothelial SOCS3 maintains homeostasis and promotes survival in endotoxemic mice

N. Martino, R. Bossardi Ramos, S. Lu, K. Leyden, L. Tomaszek, S. Sadhu, G. Fredman, A. Jaitovich, P. A. Vincent, A. P. Adam

This paper shows that endothelial SOCS3 prevents shock-induced organ failure by inhibiting IL-6 signaling and maintaining vascular barrier function.

bioRxiv · Dec 28, 2020Cell Biology

Wavelength-encoded laser particles for massively-multiplexed cell tagging

N. Martino, S. J. J. Kwok, A. C. Liapis, S. Forward, H. Jang, H.-M. Kim, S. J. Wu, J. Wu, P. H. Dannenberg, S.-J. Jang, Y.-H. Lee, S.-H. Yun

This paper introduces laser particles for multiplexed cell tagging and imaging, demonstrating their stability, biocompatibility, and ability to track individual cells in 3D tumor models.

bioRxiv · Nov 7, 2018Biophysics