Author

B. E. Dubrule

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Assay:proteomics· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Organism:yeast· 1

Frequent Co-Authors

A. Bhavsar· 1 shared A. J. Middleton· 1 shared A. P. Bhavsar· 1 shared A. S. Subramanian· 1 shared A. Wagner· 1 shared C. Delyea· 1 shared G. Eitzen· 1 shared O. Julien· 1 shared

Activity by Year

2021-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperMicrobiology

A. Bhavsar

Mutual co-authors in cluster

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2 papers

Recent·Most cited

Engineered Ubiquitin Variants Mitigate Pathogenic Bacterial Ubiquitin Ligase Function

B. E. Dubrule, A. Wagner, W. Zhang, A. J. Middleton, A. S. Subramanian, G. Eitzen, S. S. Sidhu, A. Bhavsar

This paper identifies engineered ubiquitin variants that suppress Salmonella NEL SspH1 toxicity in yeast by modulating ubiquitination activity and cell cycle interference.

bioRxiv · May 1, 2024 · PreprintMicrobiology

NOD1 is super-activated through spatially-selective ubiquitination by the Salmonella effector SspH2

C. Delyea, S. Y. Luo, B. E. Dubrule, O. Julien, A. P. Bhavsar

This paper identifies SspH2 as an E3 ubiquitin ligase that super-activates NOD1 and NOD2 through spatially-selective ubiquitination, enhancing pro-inflammatory cytokine secretion via the NF-κB pathway.

bioRxiv · Oct 8, 2021 · PreprintMicrobiology