15-PGDH Inhibition Activates the Splenic Niche to Promote Hematopoietic Regeneration
J. N. P. Smith, D. M. Dawson, K. F. Christo, A. P. Jogasuria, M. J. Cameron, M. I. Antczak, J. M. Ready, S. L. Gerson, S. D. Markowitz, A. B. Desai
This study shows that inhibiting 15-PGDH enhances splenic support for hematopoietic stem and progenitor cells, improving hematopoietic regeneration after bone marrow transplantation.
bioRxiv · Sep 17, 2020Cell Biology