Author

A. S. Frangakis

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 3 Biophysics· 2 Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:human· 4 Assay:electronic health records· 3 Research Focus:cell type annotation· 2 Research Focus:host-pathogen & immune response· 2 Assay:bulk RNA-seq· 1 Research Focus:chromatin & epigenetic regulation· 1 Assay:cryo-EM· 1

Frequent Co-Authors

M. P. Scheffer· 2 shared U. H. Ermel· 2 shared A. Dendorfer· 1 shared A. Hansen· 1 shared A. Ishida-Yamamoto· 1 shared A. Kubo· 1 shared A. L. Caldara· 1 shared A. L. Mattheyses· 1 shared

Activity by Year

2018-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 14 mutual co-author links

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2 shared papersCell Biology

M. P. Scheffer

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Author profile →

6 papers

Recent·Most cited

The molecular architecture of the kidney slit diaphragm

A. N. Birtasu, K. Wieland, U. H. Ermel, J. V. Rahm, M. P. Scheffer, B. Flottmann, M. Heilemann, F. Grahammer, A. S. Frangakis

The paper uses advanced imaging techniques to elucidate the molecular architecture of the kidney slit diaphragm, revealing a fishnet-like structure and interactions between key proteins.

bioRxiv · Oct 27, 2023Cell Biology

ArtiaX: An Electron Tomography Toolbox for the Interactive Handling of Sub-Tomograms in UCSF ChimeraX

U. H. Ermel, S. M. Arghittu, A. S. Frangakis

ArtiaX is a plugin for UCSF ChimeraX that enables interactive handling of sub-tomograms for cryo-electron tomography analysis.

bioRxiv · Jul 26, 2022Biophysics

The immunodominant protein P116 extracts cholesterol and other essential lipids

L. Sprankel, D. Vizarraga, J. Martin, S. Manger, J. Meier-Credo, M. Marcos, J. Julve, N. Rotllan, M. P. Scheffer, J. C. Escola-Gil, J. Langer, J. Pinyol, I. Fita, A. S. Frangakis

This paper identifies P116 as a lipid-extracting protein from Mycoplasma pneumoniae, revealing its structural mechanism for extracting cholesterol and other lipids from host environments.

bioRxiv · Jun 28, 2022 · PreprintBiophysics

SARS-CoV-2 infects and induces cytotoxic effects in human cardiomyocytes

D. Bojkova, J. Wagner, M. Shumliakivska, G. Aslan, U. Saleem, A. Hansen, G. Luxan, S. Guenther, M. D. Pham, J. Krishnan, P. Harter, U. Ermel, A. S. Frangakis, A. Zeiher, H. Milting, , S. Dimmeler

This study shows SARS-CoV-2 infects human cardiomyocytes, causing cytotoxicity and apoptosis, and confirms this in cardiac tissue models.

bioRxiv · Jun 1, 2020Cell Biology

The Desmosome is a Mesoscale Lipid Raft-Like Membrane Domain

J. D. Lewis, A. L. Caldara, S. E. Zimmer, A. Seybold, N. L. Strong, S. N. Stahley, A. S. Frangakis, I. Levental, J. K. Wahl, A. L. Mattheyses, T. Sasaki, K. Nakabayashi, K. Hata, Y. Matsubara, A. Ishida-Yamamoto, , A. P. Kowalczyk

The paper identifies a mutation in the desmoglein TMD that disrupts lipid raft association and desmosome formation, revealing a mesoscale lipid raft-like domain in desmosomes.

bioRxiv · Oct 15, 2018Cell Biology

The molecular recognition of phosphatidic acid by an amphipathic helix in Opi1

R. Ernst, M. Gecht, S. Fischer, A. Seybert, A. S. Frangakis, E. Stelzer, R. Covino, G. Hummer, H. F. Hofbauer

This study identifies an amphipathic helix in Opi1 that selectively binds phosphatidic acid over phosphatidylserine, revealing lipid headgroup selectivity in membrane recognition.

bioRxiv · Jan 18, 2018Biochemistry