Author

A. P. Mancuso

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3 Biophysics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:protein structure prediction· 2 Assay:structural biology· 2 Assay:cryo-EM· 1 Organism:Drosophila· 1 Organism:E. coli· 1 Organism:human· 1 Assay:imaging· 1

Frequent Co-Authors

J. Bielecki· 3 shared C. Kim· 2 shared H. Han· 2 shared H. N. Chapman· 2 shared K. Doerner· 2 shared L. Gelisio· 2 shared P. L. Xavier· 2 shared R. de Wijn· 2 shared

Activity by Year

2022-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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3 shared papersBiochemistry

J. Bielecki

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Author profile →

4 papers

Recent·Most cited

Minimized Sample Consumption for Time-Resolved Serial Crystallography Applied to the Redox Cycle of Human NQO1

D. Doppler, A. Grieco, D. Koh, A. Manna, A. Ansari, R. Alvarez, K. Karpos, H. Le, M. Sonker, G. Ketawala, S. Mahmud, I. Quereda Moraleda, A. L. Pey, R. Letrun, K. Doerner, , A. Ros

This paper demonstrates a method to reduce sample consumption in time-resolved serial crystallography by using segmented droplet generation and mix-and-inject approaches for studying NQO1's redox cycle.

bioRxiv · Apr 29, 2024Biochemistry

Observation of a single protein by ultrafast X-ray diffraction

T. Ekeberg, D. Assalauova, J. Bielecki, R. Boll, B. J. Daurer, L. A. Eichacker, L. E. Franken, D. E. Galli, L. Gelisio, L. Gumprecht, L. H. Gunn, J. Hajdu, R. Hartmann, D. Hasse, A. Ignatenko, , F. R Maia

The paper demonstrates the first X-ray diffraction pattern from a single protein, Escherichia coli GroEL, showing the feasibility of ultrafast imaging of single proteins.

Light: Science & Applications · Jan 12, 2024Peer-reviewedBiophysics

Heterologous expression, purification and structural features of native Dictyostelium discoideum dye-decolorizing peroxidase bound to a natively incorporated heme

O. Kalkan, S. Kantamneni, L. Brings, H. Han, A. P. Mancuso, F. H. M. Koua

This study expresses and purifies a functional DdDyP peroxidase with native heme incorporation, determines its structure, and reveals key catalytic site features.

bioRxiv · May 8, 2023 · PreprintBiochemistry

Structure of the Lysinibacillus sphaericus Tpp49Aa1 pesticidal protein elucidated from natural crystals using MHz-SFX

L. J. Williamson, M. Galchenkova, H. L. Best, R. J. Bean, A. Munke, S. Awel, G. Pena, J. Knoska, R. Schubert, K. Doerner, H.-W. Park, D. K. Bideshi, A. Henkel, V. Kremling, B. Klopprogge, , D. Oberthur

This paper determines the structure of Tpp49Aa1 using MHz-SFX and investigates its interaction with Cry48Aa1, expanding its known target range to include additional mosquito species.

bioRxiv · Jan 14, 2022 · PreprintBiochemistry