H. N. Chapman

SARS-CoV-2 methyltransferase nsp10-16 in complex with natural and drug-like purine analogs for guiding structure-based drug discovery

The paper identifies ligands binding to the SARS-CoV-2 nsp10-16 complex using X-ray crystallography and reports their structures, providing insights for drug discovery.

Observation of a single protein by ultrafast X-ray diffraction

The paper demonstrates the first X-ray diffraction pattern from a single protein, Escherichia coli GroEL, showing the feasibility of ultrafast imaging of single proteins.

Structural elucidation and antiviral activity of cathepsin L inhibitors with carbonyl and epoxide warheads

The paper presents crystal structures of cathepsin L inhibitors and evaluates their antiviral activity against SARS-CoV-2.

JINXED: Just in time crystallization for easy structure determination of biological macromolecules

The paper introduces JINXED, a method that combines protein crystallization and data collection in one step to improve data quality and enable time-resolved experiments.

Structure of the Lysinibacillus sphaericus Tpp49Aa1 pesticidal protein elucidated from natural crystals using MHz-SFX

This paper determines the structure of Tpp49Aa1 using MHz-SFX and investigates its interaction with Cry48Aa1, expanding its known target range to include additional mosquito species.

Enzyme Intermediates Captured "on-the-fly" by Mix-and-Inject Serial Crystallography

This paper demonstrates a method to capture enzyme reactions in real-time using mix-and-inject serial crystallography, revealing antibiotic cleavage and kinetic transitions in Mycobacterium tuberculosis β-lactamase.