Author

L. Brings

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3 Biophysics· 1 Plant Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:protein folding & dynamics· 2 Assay:structural biology· 2 Organism:Arabidopsis· 1 Approach:biophysical modeling· 1 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Assay:DNA methylation· 1

Frequent Co-Authors

C. Schmidt· 3 shared H. Han· 3 shared K. Lorenzen· 3 shared R. Schubert· 3 shared F. H. M. Koua· 2 shared A. Chretien· 1 shared A. Luana C Barra· 1 shared A. Mancuso· 1 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 32 mutual co-author links

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3 shared papersBiochemistry

C. Schmidt

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Light-induced Trpin/Metout switching during BLUF domain activation in ATP-bound photoactivatable adenylate cyclase OaPAC

A. Chretien, M. F. Nagel, S. Botha, R. de Wijn, L. Brings, K. Doerner, H. Han, J. C. P. Koliyadu, R. Letrun, A. Round, T. Sato, C. Schmidt, R.-C. Secareanu, D. von Stetten, M. Vakili, , R. Schubert

This study investigates the light-induced structural changes in OaPAC's BLUF domain, revealing a Trpin/Metout transition and conformational shifts during ATP activation.

bioRxiv · Sep 5, 2023Biochemistry

Heterologous expression, purification and structural features of native Dictyostelium discoideum dye-decolorizing peroxidase bound to a natively incorporated heme

O. Kalkan, S. Kantamneni, L. Brings, H. Han, A. P. Mancuso, F. H. M. Koua

This study expresses and purifies a functional DdDyP peroxidase with native heme incorporation, determines its structure, and reveals key catalytic site features.

bioRxiv · May 8, 2023 · PreprintBiochemistry

SARS-CoV-2 papain-like protease PLpro in complex with natural compounds reveal allosteric sites for antiviral drug design

V. Srinivasan, H. Brognaro, P. R. Prabhu, E. E. de Souza, S. Guenther, P. Y. A. Reinke, T. J. Lane, H. Ginn, H. Han, W. Ewert, J. Sprenger, F. H. M. Koua, S. Falke, N. Werner, H. Andaleeb, , P

This study identifies three natural compounds that inhibit SARS-CoV-2 PLpro by binding to the ISG15/Ub-S2 allosteric site, showing antiviral activity and potential for drug design.

Communications Biology · Aug 11, 2022Peer-reviewedBiochemistry

Hallmarks of Alpha- and Betacoronavirus non-structural protein 7+8 complexes

B. Krichel, G. Bylapudi, C. Schmidt, C. Blanchet, R. Schubert, L. Brings, M. Koehler, R. Zenobi, D. Svergun, K. Lorenzen, R. Madhugiri, J. Ziebuhr, C. Uetrecht

This study determines the stoichiometry and topology of nsp7+8 complexes from seven coronaviruses using mass spectrometry and biophysical techniques, revealing three clustering groups with distinct assembly patterns.

bioRxiv · Sep 30, 2020Biophysics

Mitochondrial nucleoid organization and biogenesis of complex I require mTERF18/SHOT1 and ATAD3 in Arabidopsis thaliana.

M. Kim, V. Schulz, L. Brings, T. Schoeller, K. Kuehn, E. Vierling

This study identifies mTERF18/SHOT1 and ATAD3 homologs as critical for mitochondrial nucleoid organization and complex I biogenesis in Arabidopsis, leading to heat tolerance.

bioRxiv · May 11, 2020Plant Biology