Author

A. A. Cluntun

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Cancer Biology· 1 Cell Biology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Research Focus:metabolism & bioenergetics· 4 Assay:metabolomics· 4 Research Focus:cell signaling & trafficking· 3 Approach:experimental assay· 3 Research Focus:cancer & tumor microenvironment· 2 Organism:human· 2 Organism:mouse· 2 Approach:deep learning· 1

Frequent Co-Authors

J. Rutter· 5 shared J. A. Berg· 3 shared Y. Ouyang· 3 shared C. N. Cunningham· 2 shared J. E. Cox· 2 shared J. M. Winter· 2 shared A. Blevins· 1 shared A. G. Toshniwal· 1 shared

Activity by Year

2020-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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5 shared papersBiochemistry

J. Rutter

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Author profile →

5 papers

Recent·Most cited

Enhancing mitochondrial pyruvate metabolism ameliorates myocardial ischemic reperfusion injury.

J. R. Visker, A. A. Cluntun, J. N. Velasco-Silva, D. R. Eberhardt, T. S. Shankar, R. Hamouche, J. Ling, H. Kwak, Y. Hillas, I. Aist, E. Tseliou, S. Navankasattusas, D. Chaudhuri, G. S. Ducker, S. G. Drakos, J. Rutter

This study shows that inhibiting MCT4 to redirect pyruvate metabolism reduces myocardial ischemia-reperfusion injury by improving mitochondrial function and reducing oxidative stress.

bioRxiv · Feb 1, 2024 · PreprintPhysiology

Phosphate Starvation Signaling Increases Mitochondrial Membrane Potential through Respiration-independent Mechanisms

Y. Ouyang, C. N. Cunningham, J. A. Berg, A. G. Toshniwal, C. E. Hughes, J. G. Van Vranken, M.-Y. Jeong, A. A. Cluntun, G. Lam, J. M. Winter, E. Akdogan, K. K. Dove, S. P. Gygi, C. D. Dunn, D. R. Winge, J. Rutter

The paper shows phosphate starvation increases mitochondrial membrane potential through respiration-independent mechanisms in yeast and mammalian cells.

bioRxiv · Oct 25, 2022Cell Biology

Protein-Metabolite Interactomics Reveals Novel Regulation of Carbohydrate Metabolism

K. G. Hicks, A. A. Cluntun, H. L. Schubert, S. R. Hackett, J. A. Berg, P. G. Leonard, M. A. Ajalla Aleixo, A. Blevins, P. Barta, S. Tilley, S. Fogarty, J. M. Winter, H.-C. Ahn, K. N. Allen, S. Block, , J. Rutter

The paper develops the MIDAS platform to identify protein-metabolite interactions, revealing novel regulatory mechanisms in carbohydrate metabolism.

bioRxiv · Aug 28, 2021 · PreprintBiochemistry

Mitochondrial pyruvate supports lymphoma proliferation by fueling a non-canonical glutamine metabolism pathway

P. Wei, A. J. Bott, A. A. Cluntun, J. T. Morgan, C. N. Cunningham, J. C. Schell, Y. Ouyang, S. B. Ficarro, J. A. Marto, N. N. Danial, R. J. DeBerardinis, J. Rutter

This study identifies a non-canonical glutamine metabolism pathway in DLBCLs where mitochondrial pyruvate supports glutaminolysis and proliferation, particularly in solid extracellular matrix environments.

bioRxiv · Aug 26, 2021 · PreprintCancer Biology

Network-aware reaction pattern recognition reveals regulatory signatures of mitochondrial dysfunction

J. A. Berg, Y. Zhou, Y. Ouyang, T. C. Waller, A. A. Cluntun, M. E. Conway, S. M. Nowinski, T. Van Ry, I. George, J. E. Cox, B. Wang, J. Rutter

The paper introduces Metaboverse, a tool for network-aware reaction pattern recognition in metabolic data, identifying regulatory signatures of mitochondrial dysfunction in lung adenocarcinoma and respiratory deficiency models.

bioRxiv · Jun 25, 2020 · PreprintBiochemistry