Author

J. A. Berg

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3 Cancer Biology· 2 Cell Biology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Organism:human· 4 Research Focus:differential expression· 3 Research Focus:cancer & tumor microenvironment· 2 Research Focus:cell signaling & trafficking· 2 Research Focus:metabolism & bioenergetics· 2 Assay:metabolomics· 2 Organism:mouse· 2

Frequent Co-Authors

J. Rutter· 6 shared J. M. Winter· 4 shared A. A. Cluntun· 3 shared J. E. Cox· 3 shared S. Fogarty· 3 shared S. P. Gygi· 3 shared Y. Ouyang· 3 shared C. N. Cunningham· 2 shared

Activity by Year

2020-2022 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 40 mutual co-author links

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6 shared papersBiochemistry

J. Rutter

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

Phosphate Starvation Signaling Increases Mitochondrial Membrane Potential through Respiration-independent Mechanisms

Y. Ouyang, C. N. Cunningham, J. A. Berg, A. G. Toshniwal, C. E. Hughes, J. G. Van Vranken, M.-Y. Jeong, A. A. Cluntun, G. Lam, J. M. Winter, E. Akdogan, K. K. Dove, S. P. Gygi, C. D. Dunn, D. R. Winge, J. Rutter

The paper shows phosphate starvation increases mitochondrial membrane potential through respiration-independent mechanisms in yeast and mammalian cells.

bioRxiv · Oct 25, 2022Cell Biology

PGC-1β and ERRα promote glutamine metabolism and colorectal cancer survival via transcriptional regulation of PCK2

D. E. Frodyma, T. C. Troia, J. A. Berg, C. Rao, R. A. Svoboda, D. D. Shinde, V. C. Thomas, R. E. Lewis, K. W. Fisher

This study identifies PCK2 as a target of PGC-1β and ERRα that promotes glutamine metabolism and colorectal cancer survival through transcriptional regulation.

bioRxiv · May 20, 2022 · PreprintCancer Biology

Protein-Metabolite Interactomics Reveals Novel Regulation of Carbohydrate Metabolism

K. G. Hicks, A. A. Cluntun, H. L. Schubert, S. R. Hackett, J. A. Berg, P. G. Leonard, M. A. Ajalla Aleixo, A. Blevins, P. Barta, S. Tilley, S. Fogarty, J. M. Winter, H.-C. Ahn, K. N. Allen, S. Block, , J. Rutter

The paper develops the MIDAS platform to identify protein-metabolite interactions, revealing novel regulatory mechanisms in carbohydrate metabolism.

bioRxiv · Aug 28, 2021 · PreprintBiochemistry

Co-deletion of ATAD1 with PTEN primes cells for BIM-mediated apoptosis

J. M. Winter, H. L. Fresenius, H. R. Keys, C. N. Cunningham, J. Ryan, D. Sirohi, J. A. Berg, S. R. Tripp, P. Barta, N. Agarwal, A. Letai, D. M. Sabatini, M. L. Wohlever, J. Rutter

The paper shows that co-deletion of ATAD1 with PTEN makes cancer cells more susceptible to apoptosis via BIM activation, correlating with better patient survival.

bioRxiv · Jul 1, 2021 · PreprintCancer Biology

Msp1/ATAD1 restores mitochondrial function in Zellweger Spectrum Disease

E. Nuebel, J. T. Morgan, S. Fogarty, J. M. Winter, S. Lettlova, J. A. Berg, Y.-C. Chen, C. U. Kidwell, J. A. Maschek, K. J. Clowers, C. Argyriou, L. Chen, I. Wittig, J. E. Cox, M. Roh-Johnson, , J. Rutter

The paper investigates peroxisomal dysfunction in Zellweger Spectrum Disease and shows that overexpressing ATAD1 restores mitochondrial function in patient-derived fibroblasts.

bioRxiv · Sep 19, 2020 · PreprintCell Biology

Network-aware reaction pattern recognition reveals regulatory signatures of mitochondrial dysfunction

J. A. Berg, Y. Zhou, Y. Ouyang, T. C. Waller, A. A. Cluntun, M. E. Conway, S. M. Nowinski, T. Van Ry, I. George, J. E. Cox, B. Wang, J. Rutter

The paper introduces Metaboverse, a tool for network-aware reaction pattern recognition in metabolic data, identifying regulatory signatures of mitochondrial dysfunction in lung adenocarcinoma and respiratory deficiency models.

bioRxiv · Jun 25, 2020 · PreprintBiochemistry

Mitochondrial fatty acid synthesis coordinates mitochondrial oxidative metabolism

S. M. Nowinski, A. Solmonson, S. F. Rusin, J. A. Maschek, C. L. Bensard, S. Fogarty, M.-Y. Jeong, S. Lettlova, J. A. Berg, J. T. Morgan, Y. Ouyang, B. C. Naylor, J. A. Paulo, K. Funai, J. Cox, , J. Rutter

This study shows that mitochondrial fatty acid synthesis (mtFAS) regulates electron transport chain (ETC) complexes and skeletal myoblast differentiation, linking fatty acid synthesis to oxidative metabolism.

bioRxiv · May 9, 2020Biochemistry