High Cysteinyl Leukotriene Receptor 1 Expression Correlates with Poor Survival of Uveal Melanoma Patients and Cognate Antagonist Drugs Modulate the Growth, Cancer Secretome, and Metabolism of Uveal Melanoma Cells.
K. Slater, A. B. Heeran, R. Sanz-Pamplona, H. Kalirai, A. Rahman, M. Helmi, S. Garcia-Mulero, F. O'Connell, R. Bosch, A. Portela, A. Villanueva, J. M. Piulats, W. M. Gallagher, L. D. Jensen, S. E. Coupland, , B. N. Kennedy
This paper shows high CysLT1 receptor expression in uveal melanoma correlates with poor survival and that CysLT1 antagonists inhibit tumor growth and alter cancer secretome and metabolism.
bioRxiv · Aug 23, 2020Cancer Biology