Author

L. D. Jensen

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 1 Cell Biology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Organism:zebrafish· 3 Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Approach:deep learning· 1 Research Focus:development & morphogenesis· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

B. N. Kennedy· 2 shared K. Slater· 2 shared A. B. Heeran· 1 shared A. Garcia-Rubia· 1 shared A. L. Reynolds· 1 shared A. M. Gomez Pozo· 1 shared A. Martinez· 1 shared A. Portela· 1 shared

Activity by Year

2018-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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2 shared papersCancer Biology

B. N. Kennedy

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Allosteric modulation of the CXCR4:CXCL12 axis by targeting receptor nanoclustering via the TMV-TMVI domain

E. M. Garcia-Cuesta, P. Martinez, K. Selvaraju, G. Ulltjärn, A. M. Gomez Pozo, G. D'Agostino, S. Gardeta, A. Quijada-Freire, P. Blanco Gabella, C. Roca, D. del Hoyo, R. Jimenez-Saiz, A. Garcia-Rubia, B. Soler Palacios, P. Lucas, , M. Mellado

This paper identifies a small molecule that modulates CXCR4 nanoclustering without affecting ligand binding, improving therapeutic potential over existing CXCR4 antagonists.

bioRxiv · Nov 19, 2023Cell Biology

High Cysteinyl Leukotriene Receptor 1 Expression Correlates with Poor Survival of Uveal Melanoma Patients and Cognate Antagonist Drugs Modulate the Growth, Cancer Secretome, and Metabolism of Uveal Melanoma Cells.

K. Slater, A. B. Heeran, R. Sanz-Pamplona, H. Kalirai, A. Rahman, M. Helmi, S. Garcia-Mulero, F. O'Connell, R. Bosch, A. Portela, A. Villanueva, J. M. Piulats, W. M. Gallagher, L. D. Jensen, S. E. Coupland, , B. N. Kennedy

This paper shows high CysLT1 receptor expression in uveal melanoma correlates with poor survival and that CysLT1 antagonists inhibit tumor growth and alter cancer secretome and metabolism.

bioRxiv · Aug 23, 2020Cancer Biology

Pharmacological Restoration of Visual Function in a Zebrafish Model of von-Hippel Lindau Disease

R. Ward, K. Slater, Z. Ali, A. L. Reynolds, L. D. Jensen, B. N. Kennedy

This study shows that sunitinib restores visual function and corrects vascular abnormalities in vhl-/- zebrafish, suggesting its potential therapeutic use for VHL-related retinal issues.

bioRxiv · Dec 4, 2018Pharmacology & Toxicology