Author

H. Kalirai

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Organism:zebrafish· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:differential expression· 1 Organism:human· 1

Frequent Co-Authors

S. E. Coupland· 2 shared A. B. Heeran· 1 shared A. G. Jochemsen· 1 shared A. Groenewoud· 1 shared A. Portela· 1 shared A. Rahman· 1 shared A. Villanueva· 1 shared B. N. Kennedy· 1 shared

Activity by Year

2020-2021 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersCancer Biology

S. E. Coupland

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2 papers

Recent·Most cited

Patient-derived zebrafish xenograft models reveal ferroptosis as a fatal and druggable weakness in metastatic uveal melanoma

A. Groenewoud, J. Yin, M. C. Gelmi, S. Alsafadi, F. Nemati, D. Decaudin, S. Roman-Roman, H. Kalirai, S. E. Coupland, A. G. Jochemsen, M. J. Jager, E. Snaar-Jagalska

The paper develops a zebrafish xenograft model of metastatic uveal melanoma and identifies ferroptosis as a druggable vulnerability in tumors with BAP1 loss.

bioRxiv · Oct 26, 2021 · PreprintCancer Biology

High Cysteinyl Leukotriene Receptor 1 Expression Correlates with Poor Survival of Uveal Melanoma Patients and Cognate Antagonist Drugs Modulate the Growth, Cancer Secretome, and Metabolism of Uveal Melanoma Cells.

K. Slater, A. B. Heeran, R. Sanz-Pamplona, H. Kalirai, A. Rahman, M. Helmi, S. Garcia-Mulero, F. O'Connell, R. Bosch, A. Portela, A. Villanueva, J. M. Piulats, W. M. Gallagher, L. D. Jensen, S. E. Coupland, , B. N. Kennedy

This paper shows high CysLT1 receptor expression in uveal melanoma correlates with poor survival and that CysLT1 antagonists inhibit tumor growth and alter cancer secretome and metabolism.

bioRxiv · Aug 23, 2020Cancer Biology