B. N. Kennedy

Inhibition of Metastatic Uveal Melanoma Cell Proliferation by the Histone Deacetylase 6 Inhibitor, Ricolinostat, is Linked to Altered Microphthalmia-associated Transcription Factor and Phospho-ERK Expression

This study shows that ACY-1215 inhibits metastatic uveal melanoma cell growth in vitro and in vivo by reducing p-ERK and MITF signaling.

High Cysteinyl Leukotriene Receptor 1 Expression Correlates with Poor Survival of Uveal Melanoma Patients and Cognate Antagonist Drugs Modulate the Growth, Cancer Secretome, and Metabolism of Uveal Melanoma Cells.

This paper shows high CysLT1 receptor expression in uveal melanoma correlates with poor survival and that CysLT1 antagonists inhibit tumor growth and alter cancer secretome and metabolism.

Non-photopic and photopic visual cycles differentially regulate immediate, early and late-phases of cone photoreceptor-mediated vision

This study investigates how non-photopic and photopic visual cycles regulate different phases of cone photoreceptor-mediated vision in zebrafish, revealing distinct roles of Rpe65 and Des1 in bright light vision.

Rab28 is localised to photoreceptor outer segments, regulates outer segment shedding but is not linked to retinal degeneration in zebrafish

This study investigates Rab28 localization and function in zebrafish cone photoreceptors, finding reduced outer segment shedding in mutants but no retinal degeneration.

A ciliary BBSome-ARL-6-PDE6D pathway trafficks RAB-28, a negative regulator of extracellular vesicle biogenesis

This study identifies a ciliary pathway involving RAB28, BBSome, and PDE6D that regulates extracellular vesicle biogenesis and homeostasis in C. elegans sensory organs.

Orthogonal Drug Pooling Enhances Phenotype-based Discovery of Ocular Anti-angiogenic Drugs in Zebrafish Larvae

This study uses orthogonal drug pooling to efficiently screen a chemical library in zebrafish larvae, identifying 8 compounds that inhibit eye angiogenesis.

1,4-dihydroxy Quininib Attenuates Growth of Colorectal Cancer Cells and Xenografts and Regulates the TIE-2 Signaling Pathway in Patient Tumours

This study shows that Q8, a modified quininib, inhibits colorectal cancer growth and angiogenesis by targeting the TIE-2 signaling pathway in both cell and xenograft models.

Pharmacological Restoration of Visual Function in a Zebrafish Model of von-Hippel Lindau Disease

This study shows that sunitinib restores visual function and corrects vascular abnormalities in vhl-/- zebrafish, suggesting its potential therapeutic use for VHL-related retinal issues.