Author

A. R. Offenbacher

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Biophysics· 1

Signature Assays, Organisms & Methods

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Research Focus:protein folding & dynamics· 3 Approach:experimental assay· 2 Approach:biophysical modeling· 1 Research Focus:drug response / drug discovery· 1 Assay:electronic health records· 1 Organism:fungi (other)· 1 Organism:human· 1 Organism:plant (other)· 1

Frequent Co-Authors

A. T. Iavarone· 2 shared A. Kostenko· 1 shared A. Sharma· 1 shared B. M. Hoffman· 1 shared C. L. Gee· 1 shared C. Whittington· 1 shared F. Fan· 1 shared G. Popovic· 1 shared

Activity by Year

2022-2022 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 15 mutual co-author links

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2 shared papersBiochemistry

A. T. Iavarone

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

13C ENDOR Spectroscopy-Guided MD Computations Reveals the Structure of the Enzyme-Substrate Complex of an Active, N-linked Glycosylated Lipoxygenase

A. Sharma, C. Whittington, M. Jabed, S. G. Hill, A. Kostenko, T. Yu, P. Li, B. M. Hoffman, A. R. Offenbacher

This paper uses 13C/1H ENDOR spectroscopy-guided MD simulations to determine the structure of an active fungal lipoxygenase-substrate complex, revealing evolutionary insights into enzyme function.

bioRxiv · Dec 7, 2022 · PreprintBiochemistry

Chorography and conformational dynamism of the Soluble Human Fibrinogen in solution

M. Sen, N. E. Hudson, A. R. Offenbacher, A. T. Iavarone, Q. Nguyen, K. Ray, G. Popovic, P. Manandhar, J. E. E. Pinelo

This study presents a conformationally dynamic model of soluble human fibrinogen in solution using biophysical methods, revealing internal flexibility and a complex conformational landscape.

bioRxiv · Sep 5, 2022 · PreprintBiochemistry

Temporal and Spatial Resolution of a Protein Quake that Activates Hydrogen Tunneling in Soybean Lipoxygenase

J. P. Zaragoza, A. R. Offenbacher, S. Hu, C. L. Gee, Z. M. Firestein, N. Minnetian, Z. Deng, F. Fan, A. T. Iavarone, J. P. Klinman

This study investigates hydrogen tunneling in soybean lipoxygenase using X-ray and deuterium exchange experiments, revealing a protein quake mechanism linked to catalytic activation.

bioRxiv · Mar 31, 2022 · PreprintBiophysics