FoxP3 can fold into two distinct dimerization states with divergent functional implications for T cell homeostasis
F. Leng, W. Zhang, R. Ramirez, J. Leon, Y. Zhong, J. van der Veeken, A. Rudensk, C. Benoist, S. Hur
This study shows FoxP3 can form two dimerization states, with head-to-head dimerization supporting function and swap-dimerization impairing it.
bioRxiv · Feb 8, 2022 · PreprintImmunology