A. Yildiz

Molecular interplay between HURP and Kif18A in mitotic spindle regulation

This study investigates how HURP regulates Kif18A motility and microtubule dynamics during mitosis using single-molecule imaging and Cryo-EM.

A unique and biocompatible approach for corneal collagen crosslinking in vivo

This study evaluates a novel corneal crosslinking method using ruthenium and blue light in rats, showing rapid epithelial healing and no corneal opacity by day 6.

Torques within and outside the human spindle balance twist at anaphase

The paper investigates how molecular torques balance spindle twist during anaphase in human cells, identifying factors that increase or decrease twist.

A force-sensitive mutation reveals a spindle assembly checkpoint-independent role for dynein in anaphase progression

This study identifies a mutation in dynein that causes mitotic spindle arrest independent of the spindle assembly checkpoint, revealing a load-dependent role in anaphase progression.

The Mechanism and Energetics of the Dynein Priming Stroke

This study uses molecular dynamics simulations to analyze the conformational changes and energy dynamics of the dynein linker during the power stroke.

Structure and activation of the human autophagy-initiating ULK1C:PI3KC3-C1 supercomplex

The paper determines the cryo-EM structure of the human ULK1C core and its complex with PI3KC3-C1, revealing structural changes that suggest a mechanism for autophagy initiation through supercomplex formation.

Nde1 Promotes Lis1-Mediated Activation of Dynein

This study investigates how Nde1 and Lis1 regulate dynein complex assembly and motility using in vitro reconstitution and single molecule imaging, revealing two distinct roles for Nde1 in promoting dynein activation.

Lis1 binding regulates force-induced detachment of cytoplasmic dynein from microtubules

This study shows Lis1 binding to dynein affects force-induced detachment asymmetry and slows dynein movement without altering stall forces.

Impact of Shelterin Complex on Telomere Accessibility

The paper measures how POT1 and a four-component shelterin complex affect telomere accessibility using PNA probes and FRET-PAINT, finding shelterin provides stronger protection than POT1 alone.

Omicron BA.1 and BA.2 Variants Increase the Interactions of SARS-CoV-2 Spike Glycoprotein with ACE2

This study uses molecular dynamics simulations to show that Omicron BA.1 and BA.2 variants have stronger RBD-ACE2 binding due to increased salt bridges and hydrophobic interactions.

Mitochondrial TRAK adaptors coordinate dynein and kinesin motility

The paper investigates mitochondrial transport in neurons by reconstituting the machinery in vitro, revealing how TRAK adaptors coordinate dynein and kinesin motors and how syntaphilin stalls transport in high Ca2+ regions.

Binding mechanism of neutralizing Nanobodies targeting SARS-CoV-2 Spike Glycoprotein

This study uses molecular dynamics simulations to analyze how three nanobodies bind to SARS-CoV-2 Spike RBD and affect ACE2 binding, revealing differences in their neutralizing mechanisms against variants.

The mechanism of motor inhibition by microtubule-associated proteins

This study investigates how microtubule-associated proteins (MAPs) regulate motor protein interactions, finding that MAPs inhibit motors without blocking their binding sites and that motors must interact with MAPs to move on MAP-coated microtubules.

Critical Interactions Between the SARS-CoV-2 Spike Glycoprotein and the Human ACE2 Receptor

This study identifies key interactions between SARS-CoV-2 spike protein and ACE2 receptor using MD simulations and suggests targeting hydrophobic residues for therapeutic strategies.

SARS CoV-2 nucleocapsid protein forms condensates with viral genomic RNA

This study shows that SARS-CoV-2 nucleocapsid protein forms condensates with viral RNA in vitro and in cells, driven by hydrophobic and electrostatic interactions.

The mitotic protein NuMA plays a spindle-independent role in nuclear formation and mechanics

This study shows NuMA has a spindle-independent role in forming a single, round nucleus by maintaining chromosomal compactness and nuclear mechanics.

Lis1 activates dynein motility by pairing it with dynactin

This study shows Lis1 activates dynein motility by releasing it from auto-inhibition and promoting complex formation with dynactin, enhancing transport efficiency.

Kinesin-1 and dynein use distinct mechanisms to bypass obstacles

This study shows that dynein can bypass obstacles on microtubules, while single kinesin motors stall, but teams of kinesins can bypass obstacles as effectively as dynein teams.

Dynamics of the IFT Machinery at the Ciliary Tip

The paper visualizes IFT dynamics in Chlamydomonas flagella, revealing kinesin-II dissociation as a negative feedback mechanism for flagellar length control.

Enhanced proofreading governs CRISPR-Cas9 targeting accuracy

This study identifies a mechanism by which CRISPR-Cas9 variants discriminate target mismatches and introduces a hyper-accurate variant with improved specificity.

A Conformational Checkpoint Between DNA Binding And Cleavage By CRISPR-Cas9

This study identifies a conformational checkpoint in CRISPR-Cas9 that regulates DNA cleavage by requiring divalent cations and preventing cleavage at off-target sites with sequence mismatches.