A. S. Maddox

Mechanical positive feedback and biochemical negative feedback combine to generate complex contractile oscillations in cytokinesis

The paper shows that mechanical and biochemical feedbacks combine to create complex contractile oscillations during cytokinesis.

Animal septins contain functional transmembrane domains

The paper identifies a transmembrane domain in septins from C. elegans and primates, showing it is required for membrane association and tissue integrity.

Contractile ring composition dictates kinetics of in silico contractility

The paper measures cytokinetic ring component dynamics in C. elegans and shows that realistic constriction kinetics emerge when incorporating measured composition changes into a 3D agent-based model.

Septins and a formin have distinct functions in anaphase chiral cortical rotation in the C. eleganszygote.

This study identifies distinct roles for septins and the formin CYK-1 in driving chiral cortical rotation during anaphase in C. elegans zygotes.

Bond type and discretization of non-muscle myosin II are critical for simulated contractile dynamics

This study compares different models of non-muscle myosin II ensembles to determine how bond type and discretization affect contractile dynamics in actomyosin networks.

Novel cytokinetic ring components drive negative feedback in cortical contractility

This study identifies GCK-1 and CCM-3 as novel cytokinetic ring components that form a negative feedback loop to regulate RhoA-mediated actomyosin contractility during cytokinesis and zygote polarization.

LITE microscopy: a technique for high numerical aperture, low photobleaching fluorescence imaging

The paper introduces LITE microscopy, a technique that improves resolution and brightness while reducing photodamage in fluorescence imaging.

Crosslinkers both drive and brake cytoskeletal remodeling and furrowing in cytokinesis

This study shows that both motor and non-motor crosslinkers influence cytokinetic furrowing speed, promoting contraction at low levels but braking at higher levels.