Author

F. R. Moss

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 5 Biochemistry· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Research Focus:protein folding & dynamics· 3 Assay:structural biology· 3 Assay:cryo-EM· 2 Organism:human· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1

Frequent Co-Authors

A. Frost· 3 shared S. Lisova· 3 shared F. Poitevin· 2 shared H. C. Nguyen· 2 shared I. D. Young· 2 shared M. S. Hunter· 2 shared R. G. Sierra· 2 shared S. Boutet· 2 shared

Activity by Year

2019-2023 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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3 shared papersBiophysics

A. Frost

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

Changes in an Enzyme Ensemble During Catalysis Observed by High Resolution XFEL Crystallography

N. Smith, M. Dasgupta, D. C. Wych, C. Dolamore, R. G. Sierra, S. Lisova, D. Marchany-Rivera, A. E. Cohen, S. Boutet, M. S. Hunter, C. Kupitz, F. Poitevin, F. R. Moss, A. S. Brewster, N. K. Sauter, , M. A. Wilson

The paper uses XFEL crystallography to observe conformational changes in an enzyme during catalysis, revealing ionization-linked dynamics that control catalytic activity.

bioRxiv · Aug 15, 2023Biochemistry

RNA structures and dynamics with A resolution revealed by x-ray free electron lasers

K. A. Zielinski, S. Sui, S. A. Pabit, D. A. Rivera, T. Wang, Q. Hu, M. M. Kashipathy, S. Lisova, C. B. Schaffer, V. Mariani, M. S. Hunter, C. J. Kupitz, F. R. Moss, F. P. Poitevin, T. D. Grant, L. Pollack

This paper reveals RNA structures and dynamics at near-atomic resolution using x-ray free electron lasers, showing how RNA folds through intermediate states and forms triplexes.

bioRxiv · May 24, 2023Biophysics

Structural basis of TRPV1 modulation by endogenous bioactive lipids

W. R. Arnold, A. S. Mancino, F. R. Moss, A. Frost, D. Julius, Y. Cheng

This study identifies a lipid-binding pocket in TRPV1 and shows that its occupancy by phosphoinositides modulates channel activity, with lipid ejection triggering activation.

bioRxiv · May 11, 2023Biochemistry

Structural basis for functional properties of cytochrome c oxidase

I. Ishigami, R. G. Sierra, Z. Su, A. Peck, C. Wang, F. Poitevin, S. Lisova, B. Hayes, F. R. Moss, S. Boutet, R. E. Sublett, C. H. Yoon, S.-R. Yeh, D. L. Rousseau

This study reveals the structural differences between the oxidized O state and the metastable OH state of cytochrome c oxidase using spectroscopy and crystallography, showing how Y244's protonation state affects proton translocation.

bioRxiv · Mar 20, 2023 · PreprintBiophysics

Brominated Lipid Probes Expose Structural Asymmetries in Constricted Membranes

F. R. Moss, J. Lincoff, M. Tucker, A. Mohammed, M. Grabe, A. Frost

The paper uses brominated lipids and cryo-EM to reveal structural asymmetries in constricted membranes.

bioRxiv · Aug 24, 2021Biophysics

CryoEM and AI reveal a structure of SARS-CoV-2 Nsp2, a multifunctional protein involved in key host processes.

M. Gupta, C. M. Azumaya, M. Moritz, S. Pourmal, A. Diallo, G. E. Merz, G. M. Jang, M. Bouhaddou, A. Fossati, A. F. Brilot, D. Diwanji, E. Hernandez, N. Herrera, H. T. Kratochvil, V. L. Lam, , K. I Pawar

The paper uses cryo-EM and AlphaFold2 to determine the structure of SARS-CoV-2 Nsp2, revealing its zinc-binding site and potential interactions with host proteins.

bioRxiv · May 10, 2021 · PreprintBiophysics

Membrane constriction and thinning by sequential ESCRT-III polymerization

H. C. Nguyen, N. Talledge, J. McCullough, A. Sharma, F. R. Moss, J. H. Iwasa, M. D. Vershinin, W. I. Sundquist, A. Frost

This study determines the structures of ESCRT-III filaments to show how sequential polymerization by CHMP1B and IST1 drives membrane tubulation, constriction, and thinning.

bioRxiv · Oct 11, 2019Biophysics